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ID:15207110
大小:38.00 KB
页数:12页
时间:2018-08-02
《尼可地尔改善心脏停搏液对心脏的保护作用》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、尼可地尔改善心脏停搏液对心脏的保护作用作者:史红宇,朱晓峰,战鹏,温福兴,龙村【关键词】心肌保护摘要:目的观察在HTK液和UW液中加入尼可地尔(Nicorandil)对心肌保存液保存效果的影响。方法实验分为4组:UW液(U)组;HTK液(H)组;UW液组+Nicorandil(U+N)组;HTK液+Nicorandil(H+N)组;每组8只大白鼠。麻醉和抗凝后,快速取下鼠心并悬挂在Langendorff灌注模型上灌注,测定血流动力学基础值。分别用四组保存液灌停离体鼠心并低温(4℃)浸泡保存6h。复温、复灌后再次测定血流动力学值,留取标本分别测定心肌水含量、心肌酶漏
2、出量、心肌细胞ATP和CP含量和心肌细胞超微结构变化。结果心肌血流动力学恢复率:H+N组>U+N组>H组>U组。心肌水含量:4组间差异无显著意义。灌脉流出液中心肌酶漏出量:H+N组<H组<U+N组<U组。心肌中ATP和CP含量:H+N组>U+N组>H组>U组。心肌细胞超微结构变化:H+N组心肌损害最轻,H组轻于U+N组,U组心肌损害最严重。结论HTK液和UW液都是比较合适的心肌保存液,HTK液对心肌的保护作用优于UW液,钾离子通道开放剂Nicorandil能够善器官保存液HTK液和UW液对心肌的保存效果。 关键词:HTK液;UW液;尼可地尔;心肌保护12 Th
3、eMyocardialPreservationEffectofNicorandilinHTKSolutionandUWSolution Abstract:OBJECTIVEWeinvestigatedtheefficacyofHTKsolutionandUWsolutionwithNicorandil(NCR)intheisolatedratheartmodels.METHODSTheheartsweredividedintofourgroups:UWsolution(U)group;HTKsolution(H)group;UWsolutionwithNicor
4、andil(U+N)group;HTKsolutionwithNicorandil(H+N)group.TheheartsisolatedfromWistarratsweremountedonaLangendorffapparatustoestimatebaselinehemodynamicvalues.Theywerearrestedandstoredat4℃ineachpreservationsolutionfor6hours.Therecoveryofmyocardialfunctionweremeasured.Myocardialtissuewaterco
5、ntentwasevaluated.MyocardialtissueAdenosineTriphosphate(ATP)andCreatinePhosphate(CP)contentineachgroupwerealsomeasured.Theleakageofmyocardialenzymesweremeasuredaswell.Finally,myocardialultrastructurewasobserved.RESULTSTherecoveryrateofmyocardialfunction:thegroupofH+N>thegroupofU+N&
6、gt;thegroupofH>thegroupofU.Themyocardialtissuewatercontent:therewasnosignificantchangesinfourgroups;Theleakageofmyocardialenzymes:thegroupofH+N<the12groupofH<thegroupofU+N<thegroupofU.ThelevelofATPandCPinmyocardialtissue:thegroupofH+N>thegroupofU+N>thegroupofH>the
7、groupofU.Themyocardialultrastructure:ThehistologicalchangesofmyocardialcellandthedamageofvascularendothelialcellweremoresignificantinU+NgroupcomparedwiththatinH+Ngroup.ThehistologicalchangesweresevererinUgroupthanthatinU+Ngroup.CONCLUSIONTheseresultssuggestthatHTKsolutionismoreeffecti
8、vetha
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