HAG预激方案治疗低增生性急性髓细胞白血病临床研究.pdf

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1、·222·世界中西医结合杂志2011年第6卷第3期WorldJournalofIntegratedTraditionalandWesternMedicine2011，Vo1．6，No．3·临床研究·HAG预激方案治疗低增生性急性髓细胞白血病临床研究韩乔燕孙淼王苇刘春华吴玲玉【摘要】目的探讨HAG预激方案对低增生性急性髓细胞白血病患者的临床疗效及不良反应。方法对28例低增生性急性髓细胞白血病(AML)患者采用HAG预激方案化疗，监测临床症状、体征、血常规及骨髓细胞形态学检查。结果28例患者中第1个疗程完全缓解15例，第2个疗程完全缓解5例，3例部分缓解，4例未缓解，1例治疗中死于脑出血；

2、1个疗程完全缓解率53．6％，总疗程完全缓解率71．4％，总有效率82．1％。外周血WBC低于1．0×10／L的中位时间为7．2(1一l6)d。结论HAG预激方案治疗低增生性AML近期疗效显著，不良反应轻，患者耐受性较好，且有利于减轻患者的经济负担，有一定的临床推广价值。【关键词】预激方案；急性髓细胞性白血病；粒细胞集落刺激因子ClinicalResearchofHAGPrimingInductionRegimenfortheTreatmentofLowProliferativeAcuteMyeloidLeukemiaHANQiao—yan，SUNMiao，WANGWei，LIUChu

3、n—hua，WULing—yu(JingjiangMunicipalityPeoplegHospital，JingjiangJiangsu214500)【Abstract】ObjectiveToexploretheclinicaleficacyandadversereactionofHAGpriminginduc—tionregimenforthetreatmentoflowproliterativeacutemyeloidleukemiafAML)．Methods50casesoflowproliferativeAMLweretreatedwithchemotherapyofHAGp

4、riminginductionregimen．Theclinicalsymptoms，physicalsigns，bloodroutineandmorphologicexaminationofbonemarrowandcellsweremonitored．Results0f28cases．15caseswerereleasedcompletelyafterthe1stsessionoftreatment，5caseswerereleasedcompleted觚erthe2ndsessionoftreatment．3caseswerereleasedpartially．4caseswer

5、enotreleasedand1easediedfromcerebralhemorrhage．Thecompletereleaserateafteronesessionoftreatmentwas53．6％．thecompletereleaserateafterthetotalsessionsoftreatmentwas71．4％andthetotaleffectiveratewas82．】％．ThemediantimeoftheDeripheralbloodWBC1essthan1．0×10／Lwas7．2(1～16)days．ConclusionHAGpriminginductio

6、nregimenachievessignificantshort—termeficacyonlowproliferativeAML，beingad—vantageousinmildadversereaction，goodtoleranceinpatientsandreducingtheeconomicburdenofpatients．Hence，thistherapyisvaluabletoacertainextentinclinicalpromotion．【Keywords】Priminginductionregimen；Acutemyeloidleukemia(AML)；Granu

7、locytecolonystimu—latingfactor近年来，急性髓细胞白血病(acutemyelogenous细胞集落刺激因子(G—CSF)治疗28例低增生性急leukemia，AML)的治疗有显著进展，缓解率40％～性髓细胞白血病，取得了较好疗效，现报道如下。60％，但对于骨髓增生异常综合征(myelodysplastic资料与方法syndrome，MDS)转化而来、慢性粒细胞白血病(chro-nicmyelocyticeleukem