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1、971requisiteforsuccessfuleradicationofpyogenicstreptococciwithWehaveinvestigatedacaseofdiarrhoeaina2Zyear-oldpenicillin.WehaveshownthatorallyadministeredmetronidazoleAsianchildwhohadvisitedPakistanfourmonthspreviously.achievesastatisticallysignificantreductioninth
2、eanaerobicCampylobacterandcystsofEntamcebahistolyticawereiso-tonsillarflora.Controlledstudiesareinprogresstodeterminethelatedfromthestool,andthechildwastreatedwithtwocoursestherapeuticefficacyofmetronidazoleintonsillitis.ofmetronidazole.Urologicalinvestigationswer
3、enegative.Thediarrhoearemittedandthechildwasdischargedwithoutfol-DepartmentofMicrobiologyandPublicHealthLaboratory,low-up.LutonandDunstableHospital,SHEENAREILLYExaminationofthedifferentiallycentrifugedultracentrifu-Luton,BedfordshireLU4ODZA.TREVORWILLISgationpelle
4、tofthepatient’sstoolbyelectrorimicroscopywithnegativestainingrevealedlargenumbersof"coronavirus-1ikeparticles"type34(fig.1).Thesizeandshapeoftheparticlesvariedgreatly;however,therewasaregulararrayofprojec-ARECORONAVIRUS-LIKEPARTICLESSEENINtionsaroundtheperipheryof
5、theparticles,approximately23DIARRHŒASTOOLSREALLYVIRUSES?nminlength.IncloserelationshiptotheseparticleswereSIR,-WorkersinBritain,’India,2andAustralia3havebroadsheetsofmembraneousmaterial,withoutdistinctivenoted"coronavirus-likeparticles"inthestoolsofchildrenm
6、orphology.withdiarrhoeaandalsoinpresumablynormalindividuals.TheAnanalogouspelletwasfixedinbufferedglutaraldehydeparticlescarryaregulararrayofprojectionsontheirsurface,andosmicacidandembeddedinSpurrresin,andstainedsec-ascoronavirusesdo,butthesizeandshapeofthepartic
7、lesistionswereexamined.Thematerialofthepelletconsistedhighlypleomorphic.Thereareanumberofdistincttypesofessentiallyoftwocomponents.Onewasanumberoflarge,-particle,themorphologyofwhichwillbereviewedelsewhere.4almostemptyenvelopes1.3-2-5mlongand0-5-1-5mwide,andwhosew
8、allconsistedofadoublelayerofrepeatingsubunits(fig.2).Thesubunitshadarepeatingpatternof15-41.CaulEO,PaverWK,ClarkeSKR.Coronavirusparticlesinfaecesfrompa-
