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1、DigestiveDiseasesandSciences,VoL30,No.12(December1985Supplement),pp.72S-77SCoronavirus-LikeParticlesandCampylobacterinMarmosetswithDiarrheaandColitisR.G.RUSSELL,DVM,PhD,D.A.BRIAN,DVM,PhD,A.LENHARD,DVM,L.N.D.POTGIETER,BVSc,PhD,D.GILLESPIE,DVM,andN.K.CLAPP,DVM,PhDDiar
2、rheaandcolitiswerecommonclinicalentitiessmallnumberofanimalshavingdiarrheasuggestedobservedduringarecenttwo-yearintervalinthethepresenceinthecolonyofantibodiestoamarmosetcolonylocatedatOakRidgeAssociatedcoronavirusantigenicallyrelatedtothebovineUniversities,OakRidge
3、,Tennessee.Thediarrheaentericcoronavirusbutnottheporcinetransmissi-occurredinsporadicepisodesofseveralweeksblegastroenteritisvirus.Interestingly,allofthedurationandaffectedupto5%ofallanimalsatanysevenanimalsthatdiedandexhibitedhistopatho-onetime.Theincidenceofthecol
4、itisisunknown,logicallesionsofcolitishadcoronavirus-likeparti-butitappearedtobewidespread.Histologically,clesintheircoloncontents.thecolitiswassimilartothatdescribedincotton-toptamarins(Saguinusoedipusoedipus)attheMATERIALSANDMETHODSNewEnglandPrimateCenter(1).Therew
5、asinfil-trationofpredominantlymononuclearcellsintotheMarmosetsandCollectionofFecalSamples.Ainterstitium,dilationofcryptswithflattenedepithe-colonyofapproximately500marmosetsishousedlium,andaccumulationofneutrophilsanddegener-attheMarmosetResearchCenter,OakRidgeAs-at
6、edandnecroticepithelialcellsinthelumen(2).sociatedUniversities,OakRidge,Tennessee.ThecauseofeitherthediarrheaorthecolitisisnotTheseincludethetamarinsSaguinusoedipusoedi-known,norisitknowntowhatextenttheyarepus,Saguinusfuscicollisspp.,andthecommoncausallyrelated.marm
7、osetCaliithrixjacchus.AnimalsarehousedInthisreportwedescribestudiesdemonstratingeithersinglyincagesorasfamiliesinthebreedingbothcoronavirus-likeparticlesandCampylobacterfacility.Stoolsamplesweretakenfrom107animalsinmarmosetswithdiarrhea.Coronavirus-likepar-duringatw
8、o-yearperiodoverwhichepisodesofticleswerefoundin24%andCampylobacterfetusdiarrheaoccurred.Duringoneepisodelastingtwosubsp,jejuniin20%ofsamp
