冠状病毒Coronavirusl论文-1980 CORONAVIRUS-LIKE PARTICLES IN DIARRHOEA STOOLS.pdf

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1、1250CORONAVIRUS-LIKEPARTICLESINDIARRHOEAthattakingoralcontraceptivesbeforegonadotrophinremissionhadSTOOLSbeenachievedincreasedtheriskofinvasivemoleorchoriocar-cinomaalmost3-fbldcomparedwiththosenottakingoestrogensS:R,—DrDourmashkinandcolleagues(Nov.I,p.971)repo

2、rtthatandprogestagens.9Thesedataarenotconclusivesincepatientstheyhaveseenpleomorphiccoronavirus-likeparticlesinaspecimenwerenotrandomisedto"pill"and"nopill"groupsbuttheywouldofhumanfaecesandpostulatethatthesemayhavederivedfromanseemtobeabetterbasisformolefollow-uppol

3、icythantheNewintestinalyeast-likeorganismandsuggestBlastocystis(nowbelievedEnglanddata.tobeaprotozoon1).Wehavedescribedcoronavirus-likeparticlesinhumanfaeces.2-5DepartmentofMedicalOncologyTheseandObstetricsandGynaecology,arequitedifferentfromthecellularmaterialwithil

4、l-definedCharingCrossHospital,fringes3whichiscommonlypresentinhumanfaecalmaterial.ToLondonW68RFK.D.BAGSHAWEdateonestrainofthecoronavirus-likeparticlehasbeenshowntoincellandorganculture5DepartmentofObstetricsandGynaecology,replicatesystemsproducingRoyalGwentHospital,u

5、ltrastructuralchangeswhichareindistinguishablefromthoseNewportMARTINSTONEproducedbyabovinecoronavirusinasimilarintestinalorganculturesystem.6,7Thesectionedparticlesseeninsidethecellsweretypicalofcoronaviruses.WeconcludedthattheparticleswereDRUGSAFETYINPORPHYRIAenteri

6、ccoronaviruses.AcommonfeatureoftheseentericSiR,-DrGorchein(July19,p.152)commentsonourletter.lcoronavirusesistheirpleomorphism,afindingwhichisnotunusualwithenvelopedRNAviruses,beforePerhapsweshouldhavepointedoutmoreclearlythatweknewthatespeciallytheyareadaptedtoinduct

7、ionof6-aminolaevulinicacidsynthetaseisadoserelatedinvitroculture.Theaboveevidenceoftheviralphenomenon.Moreover,ingeneral,thereexistsalargespeciesnatureoftheseparticlesmustbevariationintherapeuticortoxiceffectsofchemicalsubstances,andconsideredagainstthefindingsofDour

8、mashkinetal.,whoadditionallyaninterspeciesdifferenceexistsindrugmetabolismconcludedthattheparticlestheysawwereprobablynotviruses.Th