冠状病毒Coronavirusl论文-1984 IMMUNOLOGIC STUDIES OF ENTERIC CORONAVIRUS-LIKE PARTICLES(CVLP).pdf

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1、INFECTIOUSDISEASES1104CYTOMEGALOVIREMIAINHEALTHYASYMPTOMATICPREGNANTTHEUSEOFHOMOLOGOUSANDHETEROLOGOUSADOLESCENTS,DavidJ.Lang,JohnF.Kummer,Sherrie"f107ROTAVIRUSANTIBODIESFORTHEPREVENTIONOFE.ZweiqandMaryJ.Lang,CityofHopeMedicalROTAVIRUSGASTROENTERITIS.Gene

2、vieveA.LosonskyCenter.Dlv.ofPediatrics.DuarteCalifornia91010.JosephEiden,SteveVonderfecht,RobertYolken,Dept.ofPediatricsandBaseduponclinicalobservationsithasbeendeducedthatComparativeMedicine,JohnsHopkinsSchoolofMedicine,Baltimore,humancytomeqalovirus(HC

3、MV)maybetransmittedwithblood.Maryland.Ithasbeenestimatedthatapproximately5%ofhealthyRotavirusisanimportantcauseofseriousgastroenteritisinchildren.individualsareasymptomaticcarriersofHCMVinblood.Onepossiblestrategyforthepreventionofrotavirusgastroenteriti

4、sisAlthoughisolationofthisvirusfrombloodisrelativelytheoraladministrationofrotavirusspecificimmunoglobulin.WeeasilyaccomplishedinimmunosuppressedindividualsorfromutilizedamousemodelofrotavirusinfectiontoexaminetheefficacyofthosewithsymptomaticHCMV-associ

5、atedclinicalconditions,rotavirusantibodyforthepreventionofsymptomaticrotavirusdiarrhea.effortstorecovervirusfromthebloodofasymptomatichealthyThismodelconsistsofthefeedingofseronegativeinfantmiceacarriershavebeenlargelyandrepeatedlyunsuccessful.Onlypredet

6、erminedamountofmurinerotavirusandantibodyandthenonereporthasdocumentedviremiainhealthyindividualsassayingtheanimalsforintestinalantigenexcretion,liquidcolonic(in1969OiosiandassociatesreportedrecoveryofHCMVfromcontents,andimmuneresponse.Wefoundthatmousese

7、rumcontainingbloodin2of35bloodbankdonors).RInthecourseofstudieshomologousantibodiestomurinerotaviruscompletelyprotectedanimalsofhealthypreqnantadolescentsinNorthCarolinaandinfromsymptomaticinfectionandviralsheddingwhilenon-immuneserumMaryland,HCMVwasreco

8、veredfromthebloodin5of96andprovidednoprotection.Neitherimmunenornon-immunemousemilk2of41subjectsrespectively,or5%ineachpopulation.offeredanyprotectionfrominfection.InthecaseofheterologousTherewasnodemonstrableassociationwi