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1、KiinischeKlinWochenschr(1985)63:68-72Wochen-schrift~)Springer-Verlag1985DetectionofCoronavirus-LikeParticlesinHomosexualMenwithAcquiredImmunodeficiencyandRelatedLymphadenopathySyndromeP.Kern1,G.Mfiller2H.Schmitz2,p.R/tcz3,W.Meigel4,G.Riethmfiller5,andM.Dietrich1Klinisch
2、eAbteilung,zAbteilungf/irVirologie,3AbteilungffirPathologie,Bernhard-Nocht-InstitutftirSchiff~-undTropenkrankheiten,Hamburg4AbteilungfiirDermatologie,AllgemeinesKrankenhausSt.Georg,Hamburg5InstitutffirImmunologiederUniversit/itMfinchenSummary.Coronavirus-likeparticleswe
3、reidenti-initiatedintensivesearchforcausativeandoppor-fiedbyelectronmicroscopyinthefecesofhomo-tunisticinfectiousagents.Considerableevidencesexualmen.Theparticlesbandedatadensityofhasrecentlybeenaccumulatedwithregardtothe1.21g/mlaftercesiumchloridedensitygradientetiolog
4、icroleofhumanT-lymphotropicretrovir-centrifugation.TodeterminewhetherthepresenceusesLAV/HTLV-III[1,8,9].However,highpre-ofthisvirusmightberelatedtoclinicalsymptoms,valencesofantibodytoLAV/HTLV-IIIamongseveralpatientgroupswerestudiedprospectively.homosexuals[5]suggesttha
5、ttheexposuretotheIn8of16(50%)homosexualmaleswithacquiredvirusismuchmorecommonthanAIDSitself.immunodeficiencysyndrome(AIDS)orunex-Thus,hostresponsetoinfectioncanbeexpectedplainedlymphadenopathysyndrome(LAS),cor-torangefromsubclinicaltosevereandmaybeonavirusparticlesweref
6、ound.Incontrast,suchinfluencedbyconcomitantinfectiousagents.Mul-particleswerefoundinnoneof18heterosexualtipleintestinalparasiticinfestationsandothermi-controlsandinonly3of20homosexualmalescrobialinfectionsareoftenseeninhomosexualwithoutAIDSorLAS.Thus,coronavirusexcre-me
7、n[19].Inthesearchforviruses,weobservedtioncorrelatedsignificantly(2c~<0.01)withtheCVLPinthefecesofhomosexualmenandreportclinicaldiagnosisofAIDSorwithsyndromesbe-hereonaprospectivestudyforthepresenceoflongingtotheAIDS-relatedcomplex.Inaddition,theseparticlesinstoolandser
8、umspecimensofpa-suchparticlesidentifiedintheserumofonepatienttientsbelongingtoahighriskgroupofAIDS.withLASandd
