冠状病毒Coronavirusl论文-1980 CARDITIS ASSOCIATED WITH CORONAVIRUS INFECTION.pdf

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1、100soundtodate.Afurther310operationshavebeenperformedinvestigatedmorethansixmonthsaftertheacutediseasestillintheyears1975-79,inclusive,withnorecurrencestodate.hadanantibodytitreof80ormore.In1patientnoantibodiesTheseresultsconfirmtheclinicalefficiencyoftheShouldiceweredetectedinthefirstserum,tak

2、enonthefourthdayofoperationandsupportourearlierenthusiasticrecommenda-symptoms.Inalltheothersthefirstserumwastakenondaystionofthetechnique.5-12.Thisearlypresenceofantibodiesaccordswiththefind-D.DATTAingsofLeeetal.TheantibodytitresrecordedwithourspotNorthTeesGeneralHospital,Stockton-on-Tees,A.ZA

3、IDIslidemethodareofthesameorderofmagnitudeasthoseClevelandTS198PEH.BRENDANDEVLINrecordedwiththelungsectionmethod.I.2Ourresultssupportrecentfindings1,2indicatingacloseanti-genicsimilaritybetweentheKHFvirusandtheagentcausingSEN.Thefactthatage-matchedcontrolsfromthesameen-demicareaasthatoftheSENpa

4、tientswereseronegativeandSCANDINAVIANEPIDEMICNEPHROPATHYANDthefindingofapparentlylong-lastingantibodytitresafterKOREANHÆMORRHAGICFEVERSENindicatethatsubclinicalSENwithhumoralimmunere-TheLancetLeeandtheirsponseisrare.SIR,-LastyearinSvedmyranddescribedantibodiesFinnishworkers,5usingLeeimmun

5、ofluorescenttechnique,’colleaguesl.2totheKoreanhaemorrhagicfever(KHF)agentinhavefoundtheSENantigeninfrozensectionsofbankvoleserafrompatientswithScandinavianepidemic(endemic)nephropathy(SEN).Significant(Clethrionomysglareolus)lungtissue.Thusitisnowpos-titrerisessibletocomparedirectlythetwoantige

6、ns-i.e.,thatassoci-wererecordedinseveralpatients.Theseworkersusedanin-directimmunofluorescencemethod3withlungsectionsfromatedwithSENininfectedbankvolelungandKHFantigeninfectedrodents(ApodemusagrariusCorece)ininfectedA.agrariusCorecelungorininfectedA-549cells.asantigen.Wenowhave6mmdiameterspotsl

7、idesandKHFinfectedRecentlyoneofus(G.R.F.)successfullypropagatedtheKHFA-549cellsinthelaboratoryatUppsalaandhopetobeableagentonA-549humanlungcarcinomacells,andaspotslideindirectimmunofluorescencemethodhasbeendevelopedfortocollaborat