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1、599570VDIXXX10.1177/1040638715599570GlomerulonephritisinaferretwithfelinecoronavirusinfectionFujiietal.research-article2015BriefCommunicationJournalofVeterinaryDiagnosticInvestigation1–4Glomerulonephritisinaferretwithfeline©2015TheAuthor(s)Reprintsandpermissions:coronavirusinfectionsage
2、pub.com/journalsPermissions.navDOI:10.1177/1040638715599570jvdi.sagepub.com1YutaFujii,TomoakiTochitani,MamiKouchi,IzumiMatsumoto,ToruYamada,HitoshiFunabashiAbstract.Amaledomesticferret(Mustelaputoriusfuro),whichwaspurchasedfromoutsideofJapanat13weeksofage,waseuthanizedat18monthsofagebec
3、auseofpoorhealth.Atautopsy,theliver,spleen,andmesentericlymphnodewereenlarged,andwhitefociwereobservedontheoutersurfaceoftheliver.Theoutersurfaceofthemesentericlymphnodewasdarkred.Histologically,granulomaswereobservedintheliver,spleen,bonemarrow,andlymphnodes,composedmainlyofaggregatede
4、pithelioidmacrophages,someofwhichwerepositivetoananti–felinecoronavirus(FCoV;Alphacoronavirus1)antibodyinimmunohistochemistry.Mesangioproliferativeglomerulonephritiswasobserved,andperiodicacid–Schiff-positivedepositswereobservedalongglomerularcapillarywalls.Thesedepositsstainedpaleredwi
5、thperiodicacid–methenaminesilverstainandredwithMassontrichromestain,andwerealsoobservedinthemesangialmatrix.Inaffectedglomeruli,glomerularcapillarywallsandmesangialareaswerepositiveforanti-ferretimmunoglobulinG.Byelectronmicroscopy,subepithelialandmesangialelectron-densedepositswereobse
6、rvedconsistentwithimmunecomplexdeposition.ThedepositionofimmunecomplexesmayhavebeenassociatedwithFCoVinfection.Keywords:Felineinfectiousperitonitis;ferrets;glomerulonephritis;immunecomplex.Felineinfectiousperitonitis(FIP)isadiseaseofcatscaused10%neutralbufferedformalinandthenembeddedinp
7、araf-bymutatedspeciesfelinecoronavirus(FCoV;Alphacorona-fin,sectionedat3µm,andstainedwithhematoxylinandvirus1)thatisclassifiedasagroup1coronavirus.FIPcanbeeosin(HE).Sectionsofthekidneywerealsostainedusingdividedintoeffusiveanddrytypes.Thecharacteristiclesionstheperiodicacid–Sch
