中西医结合根除幽门螺杆菌90例临床观察

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1、中西更结合根除幽门螺杆菌90例临床观察［摘耍］冃的:观察中西医结合临床根除幽门螺杆菌感染的效果。方法:经胃镜和组织学检杏，选择280例Hp阳性消化性溃疡患者，随机分为三纟fl冲西医结合纟R90例,给予“三黄灭幽汤”，每天1剂，同时口服奥美拉哇胶囊,1次20mg,每天2次;西药三联组90例,给予克拉霉素片0.25g,甲硝瞠片0.4g,奥美拉呼胶囊20mg,每天2次，均口服;中药组100例，给予“三黄灭幽汤”，每天1剂,疗程均为4風疗程结朿后4周复查14C-UBT。结果:中西结合组、西药三联组及中药组I1P根除率分别

2、为92.22%,74.44%及71.00%;溃疡愈合率分别为91.11%,73.33%及72.00%。屮西医结合纟R与西药三联纟R、屮药组比较,均有非常显著性差异(P<0.01)o不良反应轻微，未见严重的肝、肾不良反应。结论：中西庾结合根除幽门螺杆菌感染疗效确切，依从性好，不良反应少，可作为二线治疗方案。［关键词］幽门螺杆菌;三黄灭幽汤;根除治疗;中西医结合;疗效评价［中图分类号］R573.1［文献标识码］A［文章编号］1673-7210(2010)01(c)-077-03Clinicalobservationo

3、n90casesofintegrationofTraditionalChineseandWesternMedicineoneradicationofHpZHANGChunshengl,LEIKaijunl,WUShengzhenl,ZHUGuochan2(LDepartmentofPharmacy,FoshanHospitalofTCM,Foshan528000,China;2.DepartmentofPharmacy,ShenzhenHospitaiofTOM,Shenzhcn518033,China)［Abs

4、tract］Objective:ToobservetheclinicaleffectofintegrationofTraditionalChineseandWesternMedicine(TCWM)oneradicationofHpinfection.Methods:Bygastroscopyandhistologytest,atotalof280patientsofHppositivepepticulcerwererandomizedinto3groups.TheTCWMgroup(90cases)wastre

5、atedbyonedoseof"SanHuangMieYouTang"perdayandOmeprazole20mgtwiceadayfor4weeks.TheTWMgroup(90cases)wastreatedbyClarithromycine0.25g,Metronidazole0・4gandOmerazole20mgtwiceadayfor4weeks.TheTCMgroup(100cases)wastreatedbyonedoseof"SanHuangMieYouTang"perdayfor4weeks

6、.14C-UBTwasdetected4weeksafterthetreatmentwasover.Results:IntheTCWM,TWMandTCMgroup,theHperadicationrateswere92.22%,74.44%and71.00%respectively,thehealingratesofpepticulcerwere91.11%,73.33%and72.00%respective!y.TheTCWMgroupvstheTWMgrouporvstheTCMgroup,therewas

7、asignificantdifferenee(P<0.01).Theadversereactionsweremild,nosevereliverorkidneyadversereactionswerefound.Conelusion:IntegrationofTCWMhasgoodeffectoneradicationofHpinfection,itshowsgoodcomplianeowithfewsideeffectssothatitcanbethechoiceofsecond-1inctreatment.［

8、Keywords］HelicobacterPylori(Hp);SanHuangMieYouTang;Eradicationtherapy;IntegrationofTraditionalChineseandWesternMedicine;Effectevaluation研究证实，幽门螺杆菌(Hp)感染是上消化道溃疡的主要致病因索。临床使用西药(三联方、四联方序贯法等)根