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1、胃肠道间质瘤诊断与治疗的临床研究[摘耍]冃的:分析胃肠道间质瘤临床常用的诊断与治疗方法,并对其方法的有效性、安全性进行研究。方法:选择2005年1月〜2010年1月在木院进行了手术治疗的胃肠道间质痫患者共65例作为治疗组,随机选择同一时段86例胃、结直肠癌患者做为对照组,比较分析治疗组与对照组的CT、消化道造影、内镜+活检资料的临床价值。将该组胃肠道间质瘤患者按照手术后是否服用甲磺酸伊马替尼分为两组,治疗组:手术+甲磺酸伊马替尼,対照组:手术。分析二者在疗效上的差异。结果:CT、消化道造影、内镜+活检等临床资料显示岀能够帮助诊断的显著性的差异。是否服用甲磺酸伊马替尼在
2、复发、转移、生存时间等方面具有显著性差异。结论:临床资料不能确诊胃肠道间质瘤,但能够提供相当准确的临床诊断;GIST术后复发率很高,甲磺酸伊马替尼对防止转移、复发、延长生存吋间有良好的疗效。[关键词]胃肠道间质瘤;甲磺酸伊马替尼;诊断;治疗[中图分类号]R735[文献标识码]B[文章编号11674-4721(2011)06(b)-136-03Clinicalresearchofgastro-intestinaltractmesenchymomadiagnosisandtreatmentLIBaifeng,WANGJing,QIJiang,TANXiangyun,LIL
3、inZhuzhouNo.1HospitalofHunanProvince,Zhuzhou412000,China[Abstract]Objective:Toanalyzetheclinicalgastrointestinalstromaltumorscommonlyusedindiagnosisandtreatment,anditsvalidityandsafetyresearch・Methods:SinceJanuary2005toJanuary2010underwentsurgeryinourhospitaltreatmentforpatientswithgast
4、rointestinalstromaltumorasatreatmentgroupwere65patients,randomlyselected65casesduringthesameperiodofgastric,colorectalcancerpatientsascontrolsgroup,comparativeanalyzedofthetreatmenlgroupandcontrolgroupCT,gastrointestinalimaging,endoscopy+biopsyintheclinicalvalueoftheinformation.Thegroup
5、ofcasesofgastrointestinalstromaltumorsaftersurgeryweretakeninaccordaneewithimatinibmesylatedividedintotwotreatmentgroups:surgeryplusimatinibmesylate,thecontrolgroup:surgery.Analyzedofthediffereneoinefficacybetweenthotwogroups・Results:CT,gastrointestinalimaging,endoscopy+biopsyandothercl
6、inicalinformationthatcanhelpdiagnosethesignificaneeofdifferences.Didtakingimatinibmesylateintherecurrence,metastasis,survivaltime,andsohadsignificantdifferences-Conelusion:Theclinicaldatacannotbediagnosedwithgastrointestinalstromaltumors,butcanprovidequiteaccurateclinicaldiagnosis;GISTr
7、ecurrcnccrateishigh,imatinibmesylatetopreventmetastasisandrecurrenee,prolongsurvivaltimeongoodeffect・[Keywords]Gastrointestinalstromaltumor;Imatinibmesylate;Diagnosis;Treatment胃肠道间质瘤(gastrointestinalstromaltumors,GIST)是--组独立起源于胃肠道间质干细胞的肿瘤,属于消化道间叶性肿瘤。消化道间叶肿瘤占的比例很少,但在消化道间叶性肿瘤中,GT