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1、77.Doi:10.1186/s12935-015-0228-7.[16]WANGX,HEX,LUC,etal.InvolvementofBimin[12]CHENC,RIDZONDA,LEEDH,etal.Real-timePhotofrin-mediatedphotodynamicallyinducedapoptosis[J].quantificationofmicroRNAsbystem-loopRT-PCR[J].CellPhysiolBiochem,2015,35(4):1527-1536.NucleicAc
2、idsRes,2005,33(20):e179.[17]SHAOYY,CHANGYL,CHENGAL,etal.Thegermline[13]LIVAKKJ,SCHMITTGENTD.AnalysisofrelativegeneBIMdeletionpolymorphismisnotassociatedwiththeexpressiondatausingreal-timequantitativePCRandthetreatmentefficacyofsorafenibinpatientswithadvanced2(-D
3、eltaDeltaC(T))Method[J].Methods,2001,25(4):hepatocellularcarcinoma[J].Oncology,2013,85(5):312-316.402-408.[18]WEBERK,HARPERN,COHENGM,etal.BIM-mediated[14]PRATHAPANA,VINEETHAVP,RAGHUKG.ProtectivemembraneinsertionoftheBAKporedomainisanessentialeffectofBoerhaaviadi
4、ffusaL.againstmitochondrialrequirementforapoptosis[J].CellRep,2013,5(2):409-420.dysfunctioninangiotensinIIinducedhypertrophyinH9c2[19]EMEAGIPU,VANLINTS,BRECKPOTK,etal.cardiomyoblastcells[J].PLoSOne,2014,9(4):e96220.ProinflammatorycharacteristicsofSMAC/DIABLO-ind
5、uced[15]ZHENGX,LIJ,LIY,etal.MicroRNA-24inducescisplatincelldeathinantitumortherapy[J].CancerRes,2012,72(6):resistancebytargetingPTENinhumantonguesquamouscell1342-1352.carcinoma[J].OralOncol,2015,51(11):998-1003.收稿日期:2015-08-29盐酸达泊西汀的合成1,221*伍平华,杜全海,陆涛(1.中国药科大学理
6、学院,南京210009;2.南京康福顺药业有限公司,南京210009)摘要:目的优化盐酸达泊西汀的合成工艺。方法以3-氯代苯丙酮为原料经还原、醚化、二甲氨基取代、拆分、成盐反应制得目标产物。结果与结论改进后的工艺简化了操作、降低了成本、较大程度上提高了收率,利于工业化生产。关键词:达泊西汀;工艺优化;选择性5-羟色胺再摄取抑制剂中图分类号:TQ460.1文献标志码:B文章编号:1007-7693(2016)02-0181-03DOI:10.13748/j.cnki.issn1007-7693.2016.02.011Im
7、provedSynthesisofDapoxetineHydrochloride1,221*WUPinghua,DUQuanhai,LUTao(1.CollegeofSciences,ChinaPharmaceuticalUniversity,Nanjing210009,China;2.NanjingKangFushunPharmaceuticalCompanyLimited,Nanjing210009,China)ABSTRACT:OBJECTIVEToimprovethemethodforthesynthesiso
8、fdapoxetinehydrochloride.METHODSStartingwith3-chloro-1-phenyl-1-propanone,dapoxetinehydrochloridewassynthesizedviaa5-stepchainreactionincludingreduction,etherificatio