microrna-30a-5p通过抑制自噬阻止肝星状细胞激活

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1、授予单位代码10089学号或申请号20123024HebeiMedicalUniversity硕士学位论文专业学位microRNA-30a-5p通过抑制自噬阻止肝星状细胞激活研究生：王存凯导师：姜慧卿教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申

2、报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名4挪j,级学院领导I,貪d河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名:目录中文摘要·····································································································

3、··1英文摘要·······································································································5英文缩写········································································································9研究论文microRNA-30a-5p通过抑制自噬阻止肝星状细胞激活前言··················

4、·····················································································10材料与方法···························································································11结果·······················································································

5、················21附图·······································································································25讨论·······································································································36结论········································

6、·······························································38参考文献·······························································································38综述microRNA在慢性肝病和肝癌中的作用··········································40致谢········································

7、·······································································56个人简历······································································································57中文摘要microRNA-30a-5p通过抑制自噬阻止肝星状细胞激活摘要肝纤维化（hepaticfibrosis,HF）是肝脏在受到诸如病毒、毒物、药物、酒精以及免疫等内外因素的持续刺激

8、时引起的以细胞外基质（extracellularmatrix,ECM）过度沉积为主要特征的慢性肝脏疾病，细胞外基质的过度沉积是肝纤维化发生的基础，而肝星状细胞（he