早期应用重组人脑利钠肽治疗急性心力衰竭的疗效探讨

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1、授予笮位代码10089学号或申请号1J495,丨na,<0河妗(£钭大交HebeiMedicalUniversity硕士学位论文在职科学学位早期应用重组人脑利钠肽治疗急性心力衰竭的疗效探讨学位申请人：李晶导师：高磊教授专业：内科学二级学院：第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否

2、则，承担相应的法律责任。研究生签名：导师签章：二级学院领导签章:年JT月4曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研宄工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研宄成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要·············································································1英文摘要·····························································

3、················4英文缩写·············································································8研究论文早期应用重组人脑利钠肽治疗急性心力衰竭的疗效评价探讨前言·············································································9材料与方法····································································10结果············

4、·································································11附图·············································································14附表·············································································15讨论···································································

5、··········18结论·············································································22参考文献·······································································22综述急性心力衰竭诊治进展··················································25致谢······························································

6、·····················34个人简历·············································································35中文摘要早期应用重组人脑利钠肽治疗急性心力衰竭的疗效探讨摘要目的：急性心力衰竭是临床上常见的内科急危重疾病，发病急，病程进展迅速。心力衰竭时心脏的结构和功能均发生了巨大变化，心脏相关生物学效应被激活，促使心力衰竭逐渐恶化，形成恶性循环。B型尿钠肽又称脑尿钠肽（Brainnatriureticpeptide，BNP），是心室扩张和心室压力负荷增加时由左心室分泌的一种心脏神经内分泌激素

7、，具有排钠、利尿、扩张血管、对抗肾素-血管紧张素-醛固酮系统(Renin-angiotensin-aldosteronesystem,RAAS)的活性，抑制交感神经过度反应，调节动脉压和血容量，进而对抗水钠潴留。外源性B型利钠肽-注射用重组人脑利钠（Recombinanthumanbrainnatriureticpeptide，rh-BNP）是DNA技术合成的生物制剂，与内源性BNP具有相同的氨基酸排序、空间结构和生物活