重组人脑利钠肽治疗急性心肌梗死后心力衰竭的疗效观察.doc

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1、重组人脑利钠肽治疗急性心肌梗死后心力衰竭的疗效观察［摘要］目的探讨重组人脑利钠钛(rhBXP)治疗急性心肌梗死后心力衰竭的临床疗效。方法将我院将2007年1月~2011年2月收治的110例急性心肌梗死心力衰竭患者随机分为对照组.和实验组，每组各55例。对照组在常规抗心衰治疗的基础上给予硝酸廿油，实验组在常规治疗的基础上加用rhBNP,分析比较两组患者用药后心功能改善情况、治疗前后的呼吸困难程度、整体临床状况、尿量及超声心动图检查。结果治疗后实验组患者的心功能改善总有效率明显优于对照组(P<0.01)；

2、实验组用药后24h、48h、72h的整体临床状况好转程度均明显高于对照组(均P<0.01);用药后24h实验组患者呼吸困难程度、尿量、尿量与入量的差值、EF值、Tei指数与对照组比较，差异有统计学意义(P<0.05)。结论rhBNP能有效改善急性心肌梗死后心力衰竭患者的呼吸困难和临床状况，提高心功能改善的总有效率，安全可靠，值得在临床推广应用。［关键词］重组人脑利钠钛；心肌梗死；心力衰竭［中图分类号］R542.2+2［文献标识码］A［文章编号］1673-7210(2012)01(c)-0044-03C

3、linicalobservationonrecombinanthumanbrainnatriureticpeptide(rhBNP)inthetreatmentoftheheartfailurepatientsafteracutemyocardialinfarction(AMI)ZENGGuopingTIANJingsongDUANShiyingTheCentralHospitalinLoudiCity,Hu'nanProvince,Loudi417000,China［Abstract］Objecti

4、veToinvestigatetheclinicalefficacyofrecombinanthumanbrainnatriureticpeptide(rhBNP)inthetreatmentofheartfailurepatientsafteracutemyocardialinfarction(AMI).Methods110caseswithheartfailureafterAMIinourhospitalfromJanuary2006toFebruary2010wererandomlydivide

5、dintocontrolgroupandexperimentgroup,andeach55cases.Thecontrolgroupwasgivennitroglycerin(NTG)onthebasisofconventionaltreatmentwhiletheexperimentgroupwasgivenrhBNPonthebasisofconventionaltreatment.Theimprovementofcardiacfunction,difficultybreathing,theove

6、rallclinicalcondition,urineandechocardiographywerecomparedbetweenthetwogroups.ResultsAftertreatment,therateofimprovedcardiacfunctionoftheexperimentgroupwassignificantlybetterthanwhichofthecontrolgroup(P<0.01);theclinicalimprovedconditionof24h>48hand72hi

7、ntheexperimentgroupwassignificantlyhigherthanwhichofthecontrolgroup(P<0.01);thereweresignificantdifferencesofthedyspnea,urineoutput,urineoutputandintakedifference,EF,Teiindexbetweentheexperimentgroupandthecontrolgroup24haftertreatment(P<0.05).Conclusion

8、rhBNPcanimprovethedyspneaandclinicalconditionsofthepatientswithheartfailureafterAMTandincreasetheoverallefficiencyofheartfunctionimproved;itissafe,reliable,andworthytopromoteintheclinical.［Keywords］Recombinanthumanbrainnatriureti