组织因子与组织因子微粒在急性髓系白血病的检测与临床意义

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1、山西医科大学硕士学位论文(2)TheresultsofMP-TFinthepatients谢廿ldifferentcoagulationindicators：111eresultsofMP．TFiIlAMLandAPL、析thdisseminatedintravascularcoagulation(DIC)werealsonosignificantdifferencethanthatInAMLandAPLwithoutDIC(P>0．05)．111eresultsofMP-TFi11t11epatientswithprothrombintime(PT)exte

2、mswerehigherthanthatinthepatients诵tllnormalPTvalue(P<0．05)．ThelevelofMP-TFinthepatientswimabnormalfibrinogendegradationproducts(FDP)valuewasnostatisticallysignificantdifferencethanthatinthepatients、^，imnormalFDPvalue(P>0．05)．(3)111elevelofTFintheAML：111elevelofTFinthepatientswithAML

3、washigherthanthatinthehealthyadults(P<0．05)．TherewerenosignificantdifferencebetweenthelevelofTFintheAMLandAPL(P>0．05)．n圮levelsofTFintheAMLandAPLwithDICbeforechemotherapywerebothhigherthanthatafterchemotherapy(P<0．001，P<0．05)．(4)TheresultsofTFinthepatientswithdifferentcoagulationindi

4、cators：TheresultsofTFintheAPL、j~ritllDICwerenosignificantdifferencethanthatintheAPLwithoutDIC(P>0．05)．111eresultsofTFinthepatients、^，itllabnormalFDPvaluewerehigherthanthatinthepmiems、杭t11normalFDPvalue(P<0．05)．nlelevelofTFinthepatients、析tllPTeXtemsWasnostatisticallysignificantdiffer

5、encethanthatinthepatientswithnormalPTvalue(P>0．05)．Conclusions：(1)ThelevelofMP-TFinthepatientswithAMLwashighexpression．ThelevelofMP-TFinthepatientswithAPLandAPL、析tllDICdecreaseda丘erchemother印y．NIP-TFcouldbeusedasafactortomonitordiseaseremission．(2)TheresultsofMP-TFinthepmiemswithhae

6、mostaticdysfunctionsuchasabnormalPTvaluewereincreasedsignificantly．MP·TFincreasesalong、杭t11prolongedPT．111elevelofFDPinthepatientswithabnormalFDPvaluewasalsoincreased．NIP．TFwasassociatedwithhaemostaticdysfunctionintheAML．V山西医科大学硕士学位论文Keywords：Microparticle·associatedTissueFactor；Acu

7、teMyeloidLeukemia；AcutePromyelocyticLeukemia；DisseminatedIntravascularCoagulationVI山西医科大学硕士学位论文刖舌急性髓系白血病(acutemyeloidleukemia,AML)是造血干细胞的恶性克隆性疾病，发病时骨髓中异常的原始细胞及幼稚细胞(白血病细胞)大量增殖并抑制正常造血。AML患者除了其本身疾病进展外常伴有凝血异常而易导致出血或血栓形成，尤其是急性早幼粒细胞白血病(acutepromyelocyticleukemia，APL)患者常存在着如弥散性血管内凝血(dissem

8、inatedintravascular