cll1在急性髓系白血病中的表达其临床意义

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1、AbstractExpressionofCLL-1inPatientswithAcuteMyeloidLeukemiaandItsClinicalSignificance．PostgraduateXiaojiaoWangSupervisorXudongWeiDepartmentofHematology，TheFirstAffiliatedHospitalofZhengzhouUniversityZhengzhou，Henan450052BackgroundAcutemyeloidleukemia(A

2、ML)iSthemostcommonformofacuteleukemia．Althoughmostpatientswithacutemyeloidleukemia(AML)achievecompleteremission(CR)afterstandardinductionchemotherapy，theprognosisofAMLispoor，andevenworseinpatientsover60yearsold．themajoritysubsequentlyrelapseanddieofthe

3、diseaseprimarilybecauseoftheresidualleukemiastemcells(LSCs)．Immunophenotype(IP)analysisbyFCMisneverthelessaveryusefultoolforfastAMLidentification．Relapseofacutemyeloidleukemia(AML)isthoughttoreflectthefailureofcurrenttherapiestoadequatelytargetleukemia

4、stemcells．Recentmultidimensionalflowcytometrichavedemonstratedthattheidentificationofaberrantimmunophenotypicpatternsmaydetectresidualleukemiawithgreatersensitivityandmaybecapableofpredictingrelapseofdisease．Althoughthecell-surfaceantigensexpressedbyAM

5、Lblastsarethesameantigensexpressedonnormalhematopoieticcells，thepatternsofcell—surfaceantigenexpressionareaberrantinmalignantmyeloidcells．Ontheotherhand，intheabsenceofleukemiaspecificmarkers，thedistinctionbetweenleukemicandnormalimmaturecellsreliesonth

6、eexpressionofantigencombinationsdefiningleukemia—associatedIP(LAIP)，whichareabsentorextremelyinfrequentinnormalbonemarrow(NBM)．TheseLAIPsareV垒鱼!!!堕!——verydifferentfrompatienttopatientandthattheyarenotstableoverthecourseofdisease．Consequently，thereissti

7、llaneedfortheideiltificationofnewantigenscontributingtodiagnosticandprognosticinformation，improvingrelapsedetection·C—typelectin．1ikemolecule．1(CLL．1)，isfoundinparticularinmyeloidcellsderivedfromperipheralbloodandbonemarrow，aswellasinthemajorityofAMLbl

8、asts．CLL-1isalsopresentonthemajorityofleukemicstemcellsintheCD34+CD38——compartmentinAMLbutabsentfromCD34+CD38——cellsinnormal111．Theidentificationofthecell—surfaceantigensCLL-1expressedbyleukemicblastsmayaidindistinguishingleukemiasofmye