拓扑替康联合顺铂方案与iep方案治疗复发性小细胞肺癌的疗效比较

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1、·1528·MODERNONCOLOGY，Aug．2010，VOI．18，NO．08[4]MitasM，MikhitarianK，WahersC，eta1．Quantitativerealtime194—198．RT—PCRdetectionofbreastcancerusingamulti-[6]ChomczynskiP，SacchiN．Sin~e—stepme~odofRNAisolationgenemarkerpanel[J]．IntJCancer，2001，93(2)：162—171．byac

2、idguanidiniumthiocyanate——phenol——cHore~rmextraction[5]BaeJW，ChoiKH，KimHG，eta1．Thedetectionofcirculating[J]．AnalBiochem，1987，162(1)：156—160．breastcancerceUsinpefipherMbloodbyreveretranscriptase一[7]金丕焕．医用统计方法[M]．上海：上海医科大学出版社，polymearsechainreaction[J]．JK

3、oreanMedSer，2000，15(2)：1992：28—29(缡校：田媛)拓扑替康联合顺铂方案与IEP方案治疗复发性小细胞肺癌的疗效比较刘显红，程颖，戴继鑫TreatmentefectsofTPandIEPregimenofrecurrentsmallcelllungcancerLIUXian—hong，CHENGYing，DAIJi—xinlinCancerHospital，Changchun130012，China．【Abstract】Objective：Tocomp~etheeficacy

4、andtoxicitybetweenTP(Topotecan+cisplatin)regimenandIEP(ifosfamide+etoposide+cisplatin)regimeninthesecond—linetreatmentofrecurrentsmallcelllungcancer(SCLC)．Methods：Totalof80casesofrecurrentsmallcelllungcancerwereenrolled．37casesweretreatedwithTPregiment(

5、Topotecan0．75mg／mivgttdl一5，DDP25mg／mivgttdl一3)；43casesweretreatedwithIEPregiment，(IFO1．2mg／mivgttdl一3，mesna400mgiv0，4，8h，dl一3，VP一16100mgivgttd1—5，DDP25mg／mivgtd1—3)．Results：ForthecasestreatedwithTPregimen，theoverallresponseratewas45．9％(17／37)，forthecase

6、switllIEPregimen，theoverallresponseratewas44．2％(19／43)(P>0．05)．Majortoxicitywasmyelosuppression．Theleueo—eytopeniaforIEPregimenwashigherthanTPregimen(55．8％versus45．9％)(P>0．05)，thrombocytopeniaforIEPregimenwashigherthanTPregimen(30．2％versus13．5％)(P<0．05)

7、，alopeciaforIEPregimenwashigherthanTPregimen(76．7％versus5．4％)(P<0．01)．Conclusion：TPandIEPregimeninthesecond—linetreat-mentofrecurrentsmallcelllungcancerhavegoodchinicaleficacyandtolerability．Theside—efectsofTPregimenarelessthanIEPregimeninrecurrentSCLC．

8、【Keywords】smallcelllungcancer；topotecan；ifosfamide；second—line；combinedchemotherapyModernOncology2010，18(08)：1528—1530【摘要】目的：比较拓扑替康联合顺铂方案与IEP方案治疗复发性小细胞肺癌的疗效和不良反应。方法：80例复发性小细胞肺癌中，37例应用拓扑替康一DDP方案(拓扑替康0．75mg／m，第1—5天静点，DDP25rag／m，第1—