[精品][经典]同期放化疗治疗中晚期鼻咽癌的疗效观察.doc

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1、［经典］同期放化疗治疗中晚期鼻咽癌的疗效观察同期放化疗治疗中晩期鼻咽癌的疗效观察【摘要】目的观察同期放化疗治疗中晩期鼻咽癌的疗效。方法100例确诊为屮晚期鼻咽癌患者随机分为同期放化疗组(A组)50例和单纯放疗组(B组)50例，A组在放射治疗的第1、4周给予2个周期顺钳加5氟尿卩密噪方案化疗；B组只给单纯放射治疗。结果A组完全缓解率84.0%(42/50)高于B组64.0%(32/50)(x²=4.18,P<0.05)；A组1、3年生存率分别为94.0%(47/50)、72・0%(36/50),高于B组88.0%(44/

2、50)、54.0%(27/50)(x²=0.80,P>0.05,x²=4.75,P<0.05)；A组局部复发率8.0%(4/50)明显低于B组26.0%(13/50)(x²=3・85,P<0.05)；A组3年远处转移率分别为14.0%(7/50)明显低于B组32.0%(16/50)(x²=4.12,P<0.05)。A组黏膜损伤54.0%(27/50)明显高于B组29.4%(10/50)(x²=4.38,P<0.05)o结论同期放化疗

3、可以降低远处转移和提高3年生存率，其毒性反应可以耐受，值得在临床中推广。❷【关键词】鼻咽癌；晚期放疗；放化疗ClinicaleffectofconcurrentchemoradiotherapyinpatientswithadvancednasopharyngealcarcinomaLANYu-hong,MAHui一min,YANGQing-xu.DepartmentofCancerRadiotherapyCentral,HuizhouCentralHospitai,Guangdong516001,China[Abstract】Object

4、iveToevaluatethecurativeeffectofradiotherapycombinedwithconcurrentchemotherapyforthetreatmentofadvancednasopharyngealcarcinoma・Methods100caseswithadvancednasopharyngealcarcinoma(stageIIIandIVa)wererandomizedinto2groups.GroupAreceivedradiotherapywithconcurrentchemotherapy(n

5、=50)andGroupBreceivedradiotherapyalone(n=50)・Agroupofradia-tiontherapyinthe1,4weekstogive2cyclesofcisplatinplus5-fluorouracilchemotherapy;Bgrouponlytoradiationtherapyalone.ResultsTherateofcompleteremissionwere84.0%(42/50)inAgrouphigherthanthe64.0%(32/50)inBgroup(x²

6、up>=4.1&P〈O・05);Theratesof1,3-yearsurvivalwere94.0%(47/50),72.0%(36/50)inAgrouphigherthanthe88.0%(44/50),54.0%(27/50)inBgroup(x²=0.80,x²=2.75,P<0.05);Therateoflocalrecurrencewere8.0percent(4/50)inAgroupweresignificantlylowerthan26.0%(13/50)inBgroup(x<

7、sup>2=3.85,P<0.05);Therateofdistantmetastasisof3-yearwere14.0%(7/50)inAGroupweresignificantlylowerthan32.0%(16/50)inBGroup(x²=4.12,P<0.05);themucosalinjurywere54.0%(27/50)inAgroupweresignificantlyhigherthan29.4%仃0/50)inBgroup(x²=4.38,P〈0・05).Con

8、clusionRadiotherapywithconcurrentchemotherapycanimprovethe3-yearsurvivalrateanddecreaseth