辅酶复合物对冷血心脏停搏液心肌保护作用的影响

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1、河北医科大学硕士学位论文辅酶复合物对冷血心脏停搏液心肌保护作用的影响姓名：顾灿申请学位级别：硕士专业：麻醉学指导教师：徐凯智201203TheeffectofcoenzymecomplexforcoldbloodcardioplegiasolutiononmyocardialprotectionABSTRACTObjective：Ithasbeendemonstratedthatthegoodmyocardialprotectiveeffectofcoenzymecomplexduringcongenitalheartdiseasetreatment

2、andcoronaryarterybyass．Butthemixtureofcoenzymecomplexandcoldbloodcardioplegiasolutionhasnotbeenreported．Toinvestigatethemyocardialprotectionofcoenzymecomplexmixedwithcoldbloodcardioplegiasolutioninadultmitralvalvereplacementsurgery．Todiscussthemyocardialprotectiveeffectofcoenzy

3、mecomplexoncardiopulmonarybypass(CPB)andtheprobablemyocardialprotectionmechanism．Methods：ThirtygradeASAIIorlIIpatients，age42to63yearsold，undergoingelectivemitralvalvereplacementsurgerywererandomlydividedintotwogroups(n=15each)．Nospiritofthehistoryofpreoperativeneuropathy,noinfe

4、ctiousdisease，withoutuncontrolledhypertension(BP≥160mmHg)，withoutanycardiacsurgery,withoutcoronaryheartdisease，diabetes，renalsystemdiseaseandothercomplications．Bodymassindex，liverandkidneyfunctionwasnormal．Inexperimentalgroup：coenzymecomplex(XinBeko)10branch(coenzymeA100U，coenz

5、ymeIO．1mgperbranch)wasmixedwithcoldbloodcardioplegiasolution，whileincontrolgroup：coldbloodcardioplegiasolutionwithoutcoenzymecomplexwasperfused．Allpatientswereinjected30rainbeforesurgeryscopolamine0．3mg．kg～，morphineO．1-4)。2mg．kg～．Afterthepatientsintotheoperatingroom，thepatients

6、’bloodpressure，heartrate，electrocardiogram，andpulseoxygensaturationweremonitored．ToopenrightupperintravenousinfusionofsodiumlactateRinger’Ssolution．Theparalledleft-invasiveradialarterybloodpressuremonitoring，acontrolbloodsamplewasobmined．Andtoinhalepureoxygenusingmask．Atthesame

7、timeintravenousmidazolam0．05--0．1ing．kg一，etomidateO．2~o．3mg．kg一，vecuroniumbromideO．1~o．2mg．kg～，andthen3英父摘要fentanyllO-20Ltg．kg—wasinjectedasabolusintoanleftarmvein．5～10minaftertheadministration，endotrachealintubationandmechanicalventilationinparalled．Donetomonitorthecentralveno

8、uspressureintemaljugularveinpuncture．Techniqueusingpro