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1、三联5日疗法根除幽门螺杆菌感染的临床疗效观察作者:王芬,沈守荣 徐灿霞,唐五良,王晓艳,贾燕,陈雄【关键词】幽门螺杆菌;雷贝拉唑;5日疗法[摘要]目的观察以雷贝拉唑(Rabeprazole,R)、奥美拉唑(Omeprazole,O)、泮托拉唑(Pantoprazole,P)为基础的三联5日疗法治疗幽门螺杆菌(H.pylori)感染的疗效。方法270例伴幽门螺杆菌感染的消化性溃疡及糜烂性胃炎患者,随机分为6组,进行三联5日疗法。选用雷贝拉唑10mg/奥美拉唑20mg/泮托拉唑40mg,分别配伍克拉霉素(Clarithromycin,C)500mg、呋喃唑酮(Furazolidone,F)10
2、0mg(5dRCF组、5dOCF组、5dPCF组)及阿莫西林(Amoxicillin,A)1g、呋喃唑酮100mg(5dRAF组、5dOAF组、5dPAF组),均为每天2次口服。用药结束后28天复查胃镜、14C呼气试验及病理检查,了解6组H.pylori根除率、药物副作用及溃疡、糜烂愈合情况。结果12H.pylori根除率:(1)ITT分析:5dRCF组73.33%,5dRAF组75.56%,均优于5dOCF组(53.33%)、5dPCF组(48.89%)、5dOAF组(55.56%)及5dPAF组(53.33%),P<0.05;(2)PP分析:5dRCF组91.67%,5dRAF组91.
3、89%,均优于5dOCF组(64.86%)、5dPCF组(57.89%)、5dOAF组(71.43%)及5dPAF组(63.16%),P<0.05;ITT分析及PP分析5dRCF组、5dRAF组之间差异均无显著性。6组副作用均少见。6组溃疡及糜烂愈合情况均较好,P>0.25。结论以雷贝拉唑为基础的短程5日疗法治疗幽门螺杆菌感染疗效确定,根除率高、副作用小,是有前途的根除H.pylori的方法。[关键词]幽门螺杆菌;雷贝拉唑;5日疗法AshortfivedayPPIbasedtripletherapyforHelicobacterpyloriinfectionWANGFen,SHENShou
4、rong,XUCanxia,etal.DepartmentofGastroenterology,theThirdXiangyaHospital,CentralSouthUniversity,Changsha410013,China[Abstract]ObjectiveToevaluatetheefficacyofa5dayrabeprazole,omeprazole,pantoprazolebasedtripletherapyforHelicobacterpylori(H.pylori)infection.Methods270H.pyloripositivepatientswithpept
5、iculcerorerosivegastritiswereselected.Thepatientswererandomizedintosixgroupsandwereassignedtoa5daytripletherapy,consistingofrabeprazole(R)10mg,omeprazole(O)20mg,pantoprazole(P)40mgtwicedaily,combinedwith12clarithromycin(C)500mg,amoxicillin(A)1000mgandfurazolidone(F)100mgtwicedaily.H.pyloristatuswa
6、scheckedbyrapidureasetestor14Cureabreathtestandhistologybeforeand4weeksaftertreatment.ResultsTheeradicationrateofH.pyloriforpatientsunder5dayRCF,OCF,PCFand5dayRAF,OAF,PAFtreatmentwere73.33%,53.33%,48.89%and75.56%,55.56%,53.33%withintentiontotreatanalysis,were91.67%,64.86%,57.89%and91.89%,71.43%,63
7、.16%withperprotocolanalysis(rabeprazolevsomeprazoleandpantoprazolecomparisonssignificant,P<0.05).Theulceranderosionhealingrateweregreat(comparisonsnotsignificant,P>0.25).Nomajorsideeffectswerereported.ConclusionF