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《2种三联疗法根除幽门螺杆菌感染胃溃疡临床疗效比较》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·2O·实用临床医学2010年第ll卷第6期PracticalClinicalMedicine,2010,Vol11,No62种三联疗法根除幽门螺杆菌感染胃溃疡临床疗效比较蒋志坚(永州市第三人民医院消化内科,湖南永州425000)摘要:目的通过比较2种治疗胃溃疡的三联疗法的治愈率和幽门螺杆菌根除率,探讨较为理想的胃溃疡治疗和幽门螺杆菌根除方案。方法选取120例感染了幽门螺杆菌的胃溃疡患者,采用随机数字表法分为A、B2组,每组6O例,分别接受硫糖铝、洛赛克和阿莫西林2周三联疗法和硫糖铝、甲硝唑和克拉霉素2周三联疗法治疗
2、,治疗结束后4周应用胃镜和活检染色对溃疡治愈率和幽门螺杆菌根除率进行分析。结果A、B2组患者溃疡治愈率差异无统计学意义(91.67VS81.67,P>0.05),但A组患者幽门螺杆菌根除率要高于B组(95.00VS81.67,P3、fTwoKindsofTripleTherapiesonEradicationofGastricUlcerInfectedwithHelicobacterPyloriJIANGZhi-jian(DepartmentofGastroenterology,theThirdPeople’SHospitalofYongzhou,Yongzhou425000,China)ABSTRACT:ObjectiveToexploreamoreidealprogramoftreatmentofgastriculcerandHelico—4、bacterpylorieradicationbycomparingthecurerateandtheHelicobacterpylorieradicationrateoftWOkindsoftripletherapiesforgastriculcer.MethodsOnehundredtwentypatientswithgastriculcerinfectedwithHelicobacterpyloriweredividedintogroupsAandBbyrandomtablemeth—od,andweretre5、atedwithsucralfate,omeprazoleandamoxicillinfortwoweeksforgroupA(n一60)orsucralfate,metronidazoleandclarithromycinfortwoweeksforgroupsB(n一60),respec—tively.TheendoscopyandbiopsystainingwereusedtoanalysisthecurerateandtheHelicobacterpylorieradicationrateatthe4thwe6、ekaftertheendofthetreatment.ResultsTherewasnodifferencebetweengroupsAandBingastriculcercurerate(91.679,6VS81.67,P>0.05),buttheHelicobacterpylorieradicationrateofgroupAwashigherthanthatofgroupB(95.00VS81.67,P<0.05).ConclusionSucralfate,omeprazoleandamoxicillintW7、O—weektripletherapyisamoreidealtreatmentprogramforgastriculcer.KEYWORDS:tripletherapy;gastriculcer;curativeeffect;Helicobacterpylori胃溃疡是临床上最常见的消化系统疾病之一,可达959/6以上,甚至接近100%[1_引。研究表明,根幽门螺杆菌(HelicobacterpylQri,Hp)是其主要致除幽门螺杆菌后溃疡复发率和并发症可明显降病因子,胃溃疡患者感染幽门螺杆菌的比例非常高,低嘲,所8、以对幽门螺杆菌阳性胃溃疡,不仅要治愈溃收稿日期:2O1O—O2—2O作者简介:蒋志坚(1959一),男,大专,副主任医师,主要从事消化性溃疡的临床治疗和研究。实用临床医学2010年第11卷第6期PracticalClinicalMedicine,2010,Vol11,No6·21·疡,还应根除幽门螺杆菌,才能减少溃疡复发。本研2.22组患者幽门
3、fTwoKindsofTripleTherapiesonEradicationofGastricUlcerInfectedwithHelicobacterPyloriJIANGZhi-jian(DepartmentofGastroenterology,theThirdPeople’SHospitalofYongzhou,Yongzhou425000,China)ABSTRACT:ObjectiveToexploreamoreidealprogramoftreatmentofgastriculcerandHelico—
4、bacterpylorieradicationbycomparingthecurerateandtheHelicobacterpylorieradicationrateoftWOkindsoftripletherapiesforgastriculcer.MethodsOnehundredtwentypatientswithgastriculcerinfectedwithHelicobacterpyloriweredividedintogroupsAandBbyrandomtablemeth—od,andweretre
5、atedwithsucralfate,omeprazoleandamoxicillinfortwoweeksforgroupA(n一60)orsucralfate,metronidazoleandclarithromycinfortwoweeksforgroupsB(n一60),respec—tively.TheendoscopyandbiopsystainingwereusedtoanalysisthecurerateandtheHelicobacterpylorieradicationrateatthe4thwe
6、ekaftertheendofthetreatment.ResultsTherewasnodifferencebetweengroupsAandBingastriculcercurerate(91.679,6VS81.67,P>0.05),buttheHelicobacterpylorieradicationrateofgroupAwashigherthanthatofgroupB(95.00VS81.67,P<0.05).ConclusionSucralfate,omeprazoleandamoxicillintW
7、O—weektripletherapyisamoreidealtreatmentprogramforgastriculcer.KEYWORDS:tripletherapy;gastriculcer;curativeeffect;Helicobacterpylori胃溃疡是临床上最常见的消化系统疾病之一,可达959/6以上,甚至接近100%[1_引。研究表明,根幽门螺杆菌(HelicobacterpylQri,Hp)是其主要致除幽门螺杆菌后溃疡复发率和并发症可明显降病因子,胃溃疡患者感染幽门螺杆菌的比例非常高,低嘲,所
8、以对幽门螺杆菌阳性胃溃疡,不仅要治愈溃收稿日期:2O1O—O2—2O作者简介:蒋志坚(1959一),男,大专,副主任医师,主要从事消化性溃疡的临床治疗和研究。实用临床医学2010年第11卷第6期PracticalClinicalMedicine,2010,Vol11,No6·21·疡,还应根除幽门螺杆菌,才能减少溃疡复发。本研2.22组患者幽门
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