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1、两种序贯疗法及十天三联疗法根除幽门螺杆菌感染疗效比较【摘要】目的评价含呋喃唑酮和含替硝唑的两种序贯疗法和十天三联疗法根除幽门螺杆菌(H.pylori)的疗效。方法将163例消化性溃疡和慢性胃炎且Hp阳性的患者随机分为3组。序贯疗法A组54例，前5d予埃索美拉唑20mg＋阿莫西林1.0g,2次/d；后5d予埃索美拉唑20mg+克拉霉素500mg＋呋喃唑酮100mg，2次/d。序贯疗法B组55例，前5d予埃索美拉唑20mg＋阿莫西林1.0g，2次/d；后5d予埃索美拉唑20mg＋克拉霉素500mg＋替硝唑500mg，2次/d。三联疗法C组54例，予埃索美拉唑20mg＋阿莫西林1.
2、0g＋克拉霉素500mg，2次/d，疗程10d。记录治疗期间发生的不良反应。疗程结束停药至少4周以上复查��14�C-UBT(尿素呼气试验),判断H.pylori根除情况。结果按试验方案(PP)分析和意向处理(ITT)分析，A组根除率分别为92.0%、85.2%；B组分别为77.6%、69.1%；C组分别为73.5%、66.7%。A组与B、C组分别相比较，差异均有统计学意义(均P0.05)。结论含呋喃唑酮的序贯疗法疗效明显高于含替硝唑序贯疗法及十天三联疗法，可以考虑作为H.pylori感染患者初治的一线治疗方案。【关键词】幽门螺杆菌感染;序贯方案;三联疗法;14根除率;呋喃唑
3、酮;替硝唑Comparativestudyontwokindsofsequentialtherapyandthe10-daystandardtripletherapyforEradicationofhelicobacterpyloriLIUJian，LIUKe-wang，MIQing-ping,etal.ThePeople�sHospitalofChenxiHuaihua419500，China【Abstract】ObjectiveToevaluatetheeradicationrateofH.pyloriwithfurazolidonebasedsequentialther
4、apy,tinidazolebasedsequentialtherapyand10-daytripletherapy.Methods163patientswithH.pyloripositivepepticulcerdiseaseorchronicgastritiswererandomlydividedintogroupA,BandC.GroupA54casesreceivedsequentialtherapy,Eesomeprazole20mgplusAmoxicillin1.0gforthefirst5days,followedbyEsomeprazole20mg,Cla
5、rithromycin500mgandFurazolidone100mgforthenext5days.GroupB55casesreceivedsequentialtherapy,Esomeprazole20mgandAmoxicillin1.0gforthefirst5days,followedbyEsomeprazole20mg,Clarithromycin500mgandTinidazole500mgfortheremaining5days.GroupC54casesreceivedtripletherapy,Esomeprazole2014mg,Amoxicilli
6、n1.0gandClarithromycin500mgfor10days.Alldrugsweregiventwicedaily.TheadverseeffectswererecordedduringthecourseoftreatmenteradicationofH.pyloriwasdeterminedby��14�C-ureabreathtest4weeksaftercompletionoftreatment.ResultsPer-protocolanalysis(PP)andintention-to-treatanalysis(ITT)eradicationrates
7、were92.0%,85.2%ingroupA,77.6%,69.1%ingroupB,and73.5%,66.7%ingroupCrespectively.EradicationratesingroupAweresignificantlyhigherthanthoseingroupBandgroupC(P0.05).ConclusionFurazolidonebasedsequentialtherapycouldachievehighereradicationrateofH.Pyloricompare
