低分子肝素治疗早发型重度子痫前期的临床资料回顾-论文.pdf

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1、中国实用医药2014年1月第9卷第3期ChinaPracMed，Jab2014，Vo1．9，NO．3·1··论著·低分子肝素治疗早发型重度子痫前期的临床资料回顾罗穗豫王瑜【摘要】目的应用低分子肝素治疗早发型重度子痫前期，探索其治疗的有效性。方法选取2012年8月～2013年8月在河南省人民医院产科住院的早发型重度子痫前期患者60例，随机分为治疗组与对照组各3O例。对照组给予硫酸镁针、心痛定片常规解痉、降压治疗，观察组在此基础上加用低分子肝素钙针(商品名：速碧林)，脐周皮下注射，4100U／d，连续7d，隔周重复疗程。比较应用低分子肝素治疗前后的凝血酶原时间

2、fprothrombintime，PT)、凝血酶时间(thrombintime，TT)、D一二聚体，用彩超多普勒测量胎儿的脐动脉、大脑中动脉的S／D值，并记录分娩结局。结果治疗组治疗前后脐动脉S／D、大脑中动脉S／D、TIP、D一二聚体的指标变化差异有统计学意义(P<0．05)。治疗后两组脐动脉S／D、大脑中动脉S／D、D一二聚体的指标变化差异有统计学意义(P<0．05)。两组的Apgar评分、出生体重、胎儿死亡率差异有统计学意义(P<0．05)。产后m血量两组差异无统计学意义。结论应用低分子肝素钙可明显改善母体的病理性高凝状态，改善新生儿预后，不增加产后

3、出血量，应用于治疗早发型重度子痫前期是安全有效的。【关键词】早发重度子痫前期；低分子肝素；病理性高凝状态Clinicaldatareviewoflowmolecularweightheparin(LMWH)onearly-onsetseverepreeclampsiaLUOSui-yu，WANGYu．DepartmentofObstetricsandGynecology,PeopleHospitalofZhengzhouUniversity(HenanPeopleHospita1)，Zhengzhou450003,China【Abstract】Object

4、iveToinvestigatetheeffectoflowmolecularweightheparin(LMWH)onearly—onsetseverepreeclampsiaandanalyzetheirpregnancyoutcomes．MethodsAtotalof60patientswithearlyonsetpreeclampsiawereselectedinHenanProvincePeople’SHospita1．Thepatientswererandomlydividedintoobservationgroup(n=30)andcontr

5、olgroup(n=30)．Thecasesofthecontrolgroupweretreatedwithmagnesiumsulfateandnifedipine．Thecasesoftheobservationgroupweretreatedwithmagnesiumsulfate，nifedipineandLMWH(FraxiParine)．ProthrombinTime(PT)，ThromhinTimefiT)，D—Dimer，S／Dvalueoffetalumbilicalandmiddlecerebralarteriesandpregnanc

6、youtcomewereobserved．ResultsS／Dvalueoffetalumbilicalandmiddlecerebralarteries，3"T，DD'aftertreatmentintheobservationgrouparedifierentwiththatofbeforetreatment．ThedifferencesofS／Dvalueoffetalumbilicalandmiddlecerebralarteries，DD，Apgarscores，birthweight，fetalmortalitybetweenthetwogro

7、upswasstatisticallysignificant(P<0．05)．Theincidenceofpostpartumhemorrhagebetweentwogroupswasshownnosignificantdifference(P>0．05)．ConclusionTheapplicationoflowmolecularheparininearlyonsetseverepreeclampsiacanimprovethehypercoagulabalestateandmaternalandfetaloutcomes．Theincidenceofp

8、ostpartumhemorhageisnotincreased．