“双固一通＂电针法对老年阳虚模型大鼠空间学习记忆与海马长时程增强的影响-论文.pdf

《“双固一通＂电针法对老年阳虚模型大鼠空间学习记忆与海马长时程增强的影响-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、中华中医药杂志(原中国医药学~)2013年12月第28卷第12期CJTCMP，December2013，Vo1．28，No．12·3717。·研究报告·“双固一通"电针法对老年阳虚模型大鼠空间学习记忆与海马长时程增强的影响郭冠华，刘建民，王静芝，刘静，吕景芳，陈明扬，王华(湖北中医药大学针灸骨伤学院，武汉430061；山西中医学院针灸推拿学院，太原030024)摘要：目的：观察“双固一通”电针法对衰老阳虚大鼠学习记忆行为以及在体海马齿状回长时程增强的影响。方法：以注射D一半乳糖和氢化可的松诱导老年阳虚模型大鼠。正常组大鼠注射等量0．9％氯化钠溶液。电针组和对照组分别采用“双固一通”法和对照腧穴

2、电针治疗。Morris水迷宫检测大鼠学习记忆行为；检测大鼠海马齿状回高频刺激诱发的群峰电位幅值变化。结果：①与模型组比较，电针组大鼠潜伏期缩短，首次跨越时间缩短，跨越次数增加(P<0．05)；②与模型组比较，电针组Ps增幅明显升高(P<0．01)。结论：“双固一通”电针法可促进老年阳虚模型大鼠的学习记忆能力，并在一定程度上提高老年阳虚模型大鼠海马齿状回长时程增强。关键字：双固一通；老年阳虚大鼠；学习记忆；长时程增强；海马基金资助：湖北省自然科学基金重点项目(No．2008CDA051)Effectsof‘double-reinforcingandone—unblocking’ofacupunc

3、turemethodonspatiallearningandmemory,LTPofagingmodelratswithYang-deficiencyGUOGuan．hua’，LIUJian．min，WANGJing．zhi，LIUJing，LVJing—fang，CHENMing-yang，WANGHua(CollegeofAcu—moxibutionandOrthopedics，HubeiUniversityofChineseMedicine，Wuhan430061，China；CollegeofAcupunctureMoxibusfionandMassage，ShanxiUniversi

4、tyofChineseMedicine，Taiyuan030024，China)Abstract：Objective：Toobservetheeffectsof‘Double—reinforcingandOne-unblocking’ofacupuncturemethodonthespatiallearningandmemo~，Long—termpotential(LTP)ofagingmodelratswithYang—deficiency．Methods：TheD—galactoseInjectionandtheHydrocortisoneInjectionwasusedtoinducet

5、heagingmodelratswithYang-deficiencysymptom．Normalratswereinjectedwiththesameamountofsaline．EARatsweretreatedwith‘Double—reinforcingandOne—unblocking’ofacupuncturemethods，andECratswerestimulatedwithcontrolelectro—acupuncturetherapy．Morriswater—mazetaskwasusedasthejudgingstandardforspatiallearningandm

6、emo~behavior．Populationspikewasusedtodetectthechangesofpotentialamplitudeinducedbythehighfrequencystimulation(HFS)．Results：@Comp~edwithmodelrats，theEArats，theescapelatencywereshorter，thefirsttimeofspatialprobingtheformerplatformwereshorter，andthenumberofspanningtheformerplatformincreased(P

7、mparedwithmodelrats，recordafterHFSindicatedthattheincidenceofLTPinductionoftheEAratswerehigher(P