声脉冲辐射力成像技术评价兔肝VX2肿瘤冷热交替治疗后弹性变化的初步研究-论文.pdf

《声脉冲辐射力成像技术评价兔肝VX2肿瘤冷热交替治疗后弹性变化的初步研究-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、中国超声医学杂志2014年5月第3O卷第5期ChineseJUltrasoundMedVo1．30No．5May2014——457——声脉冲辐射力成像技术评价兔肝VX肿瘤冷热交替治疗后弹性变化的初步研究孙迪申锷魏聪胡兵摘要目的应用声脉冲辐射力成像技术(ARFI)评价兔肝VX肿瘤冷热交替治疗后的弹性变化。方法选取9只新西兰大白兔，开腹种植肝VX肿瘤共9枚，肿瘤生长第18天进行冷热交替治疗，术前及术后1、7、14d分别应用ARFI技术进行检查，评价肿瘤消融后的弹性变化。结果术后1d消融区较术前硬(P一0．003)，术后7d与术后1d无显著差异(P=0．065)，术后14d较术

2、后1d软(P一0．010)。此外，术后7d病灶硬度不均一：中央消融区>周边带状区>外围正常肝组织，与病理相符。结论ARFI技术能够定性、定量检测兔肝VX肿瘤冷热交替治疗后不同时间的弹性变化，与病理改变相一致。关键词声脉冲辐射力成像技术冷热交替治疗肝VX肿瘤PrimaryStudyoftheAcousticRadiationForceImpluseontheElasticityofRabbitVX2LiverTumorafterAlternatedCoolingandHeatingTreatmentSunDi，ShenE，WeiCong，eta1．DepartmentofU

3、ltrasoundinMedicine，ShanghaiSixthPeople'sHospitalAffiliatedtoShanghaiJiaotongUniversity，ShanghaiInstituteofUltrasoundinMedicine，Shanghai200233ChinaAbstract：ObjectiveToevaluatetheelasticityofrabbitVX2livertumorafteralternatedcoolingandheatingtreatmentwithAcousticRadiationForceImpluse(ARFI)

4、．MethodsFirst，nineVX21ivertumormodelswereestab—lishedinninemaleNewZealandWhiteRabbitswithopentumorplant；Andthenalternatedcoolingandheatingtreat—mentwereperformedinthe18dayaftertumorplanted．ARF1wasperformedbeforetherapyandonthe1。7and14dayaftertherapytoevaluatetheelasticityofthetherapeutica

5、reaatdifferenttime．ResultsThetreatedareaonthe1。dayaftertherapyisharderthanthatbeforetherapy(P一0．003)；Onthe7day，themaintreatedareainthecentershowednomarkeddifferencewiththe1。dayaftertherapy(P一0．065)，whileonthe14dayafertherapy，itissofterthanthe1day(P=0．010)．Besides，onthe7day，theelasticityof

6、thetreatmentareaappearsheterogenous．Orderaccordingtothehardness：thetreatedareainthecenter，theperipheralstrip，andthenormallivertissues，whichisconsistentwiththepathologicalchanges．ConclusionsAcousticRadiationForceImpluse(ARFI)canexambothqualitativelyandquantitativelytheelasitcitychangesofra

7、bbitVXzlivertumorafteralternatedcoolingandheatingtreatment，andhasgoodcorrespondencetothepathologicalchanges．Keywords：Acousticradiationforceimpluse，Alternatedcoolingandheatingtreatment，VXztumorinliver声脉冲辐射力成像(acousticradiationforceim—是将单冷与单热治疗相结合以克服两者局限性的一种pulseimagi