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时间:2020-05-02
《右美托咪啶用于腹部手术全身麻醉效果及术后恢复质量的临床研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、CbinJClinPharmacoI317Vo1.30No.4Apat2014(SerialNo.174)右美托咪啶用于腹部手术全身麻醉效果及术后恢复质量的临床研究Clinicalresearchoftheefectofdexmedetomidineonpatientsundergoinga0m1-nalsurgeryandonqualityofpost·--surgeryrecovery赵栋,张明途摘要:目的探讨右美托咪啶(DEX)用于腹部手术患者的全麻效果、术后恢复质量及安全性。方法全身麻醉腹部
2、手术患者9l例随机分为试验组(44例)和对照组(47例)。对照组于麻醉诱导前15min静脉滴注生理盐水15mL,试验组静脉滴注DEX负荷剂量0.5g·kg~,随后以0.25Ixg·kg~·h的速率输注(金华市中心医院麻醉科,浙江金华321000)直至拔除气管插管。观察比较2组患者自主呼吸恢复时间、苏醒时间、拔管时间及不良反应发生率。结果试验组麻醉苏醒期VRS镇痛评分为(2.4±0.8),对照组为(3.7±1.1),试验组显著低于对照组(P<0.05);苏醒期躁动及呛咳不良ZHAODong,ZHANG
3、Ming—tu反应发生率,试验组显著低于对照组(P<0.05);2组患者自主呼吸恢复时间、拔除气管导管时间及苏醒时间差别无统计学意义(P>O.05)。结论DEX用于腹部手术患者可显著增强全身麻醉效果,降低苏醒期不良反应发生率。(DepartmentofAnesthesiology,The关键词:右美托咪啶;腹部手术;全身麻醉中图分类号:11971.2;R614.2文献标志码:ACentralHospitalofJinhua,Jinhua321000,ZhejiangProvince,China)文章
4、编号:1001—6821(2014)04—0317—03Abstract:0bjecfiveToevaluatetheclinicalefficacyandsafetyofdexmedetomidine(DEX)onpatientsundergoingabdominalsurgerywhoreceivedgeneralanesthesiaandonqualityofpost—surgeryrecovery.MethodsNinety——onepatientswhowereplanedforabdom
5、inalsurgerywithgeneralanesthesiawererandomlydividedintotreatmentgroup(n44)andcontrolgroup(n=47)withrandomnumbertable.Patientsincontrolgroupweregivensaline15mL15minpriorgeneralanesthesia.AndpatientsintreatmentgroupweregivenDEX0.5txg·kg一andthen0.25g·kg~·
6、h~intheprocedureofoperation.Spontaneousbreath—ing,awakingtime,extubationtimeandsideeffectswerecomparedbe—tweentwogroups.ResultsTheVRSanalgesicscoreintreatmentgroupwasmuchlowerthanthatincontrol(P<0.05).Theincidencerateofagitationbuckingintreatmentgroupw
7、asmuchlowerthanthatincontrolgroup(P<0.05).Butspontaneousbreathingtime,awakingtimeandextubationtimeshowednostatisticaldifferencebetweenthetwogroups(P>0.05).ConclusionDEXcansignificantlyreducetheriskofde—收稿日期:2013—07—25velopingagitation,buckingandimprove
8、thegeneralanesthesiaeficacyin修回日期:2013—10—23作者简介:赵栋(1980一),男,主治医师,主要patientsreceivingabdominalsurgerywhounderwentgeneralanesthesia.从事临床麻醉学研究Keywords:dexmedetomidine;abdominalsurgery;generalanesthesia通信作者:赵栋MP:13957974770E—mail:zhaodong0
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