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《右美托咪定减少全麻下老年女性患者妇科手术术后谵妄的临床观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、四川医学2014年6月第35卷(第6期)SichuanMedicalJournal,2014,Vo1.35,No.6·663·论著右美托咪定减少全麻下老年女性患者妇科手术术后谵妄的临床观察何鞠颖,曹蓉,彰宁(成都市妇女儿童中心医院麻醉科,四川成都610031)【摘要】目的研究右关托咪定减少全麻下老年女性患者妇科手术术后谵妄的效果。方法选择在全麻下行妇科手术的老年女性患者60例,随机分为右美托咪定组(A组),生理盐水组(B组),各30例。两组采用相同的麻醉诱导和麻醉维持方式,术后均采用一次性镇痛泵静脉镇痛。A组
2、给予右美托咪定(浓度为4g/m1)3(kg·h)持续10min,然后以右美托咪定(浓度为41xg/m1)0.3trg/(kg·h)维持至手术结束;B组给予同等剂量的生理盐水。分别记录麻醉持续时间,停药后自主呼吸恢复时间(min)、拔管时间(min)、拔管时镇静·躁动评分,拔管后15min舒适度评分,以及术后48小时患者的谵妄评定方法中文修订版评分情况。结果两组患者术中麻醉持续时间差异无统计学意义(P>0.05),停药后自主呼吸恢复时间、拔管时间、拔管时镇静.躁动评分、拔管后15min舒适度评分、术后48小时C
3、AM.CR评分情况均差异有统计学意义(P<0.05)。结论术中静脉持续微量泵入右美托咪定能够有效的减少老年女性患者妇科手术术后谵妄的发生,并且减低全麻苏醒期躁动发生率,提高患者的满意度。【关键词】右美托咪定;全麻;老年女性患者;妇科手术;术后谵妄【中图分类号】R614【文献标志码】A【文章编号】1004-0501(2014)06-0663-03DexmedetomidineImprovementofPostoperativeDeliriumFollowingGynaecologicSurgeryinElder
4、lyFemalePa-tientswithGeneralAnesthesia.HeJuyin,Cao砌,ZhangNing.ChengduWomen's&Children'sCentralHospital,Chengdu,Si—chuan610031,China【Abstract】ObjectiveToinvestigatetheresultsofdexmedetomidineimprovementofpostoperativedeliriumfollowinggynaecologicsurgeryineld
5、erlyfemalepatientsbygeneralanesthesia.Methods60casesofelderlyfemalepatientswithgynaeco·logicsurgerywereperformedgeneralanesthesia.Allcaseswererandomizedintonormaldexmedetomidinegroup(groupA,n30)andsalinegroup(groupB,n=30).ThesalineandDexmedetomidine(41~g/m1
6、)wasinfusedwith3g/(kg·h)for10min,thenpersistentlyinfusedwith0.3t~g/(kg·h)totheendofoperationingroupAandgroupB,respectively.Thefollowingvaria-bleswereanalyzed,includingthedurationofanesthesia,therecoverytimeoftheautonomousrespiration(>10bpm),theextuba—tionti
7、me,therichmondagitation·sedationscale(RASS)inextubation,thecomfortscoreafterextubation15minandtheCAMChi-nesereversionafter48hoursofoperation.ResultsTherewasnosignificantdifferenceinthedurationofanesthesiaTherecoverytimeoftheautonomousrespiration,theextubati
8、ontime,theRASSinextubation,thecomfortscoreafterextubation15minwereob—viouslydifferentbetweentwogroups(allP<0.05).TrheincidenceofpostoperativeDeliriumwassignificantlyloweringroupAthanoneingroupB.Conclus
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