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《右美托咪定对老年髋部骨折手术患者术后谵妄的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、临床麻醉学杂志2013年1O月第29卷第1O期JClinAnesthesiol,October2013,Vo1.29,No.10·1003·.临床研究.右美托咪定对老年髋部骨折手术患者术后谵妄的影响郑客松顾尔伟李查兵【摘要】目的评价右美托咪定对老年髋部骨折手术患者术后谵妄的影响。方法60例老年髋部骨折手术患者,年龄65~87岁,随机均分为右美托咪定组(D组)和对照组(C组)。D组给予右美托咪定0.5gg/kg负荷量,10min泵完后麻醉诱导同时予0.4g·kg叫·h维持;C组给予等量生理盐水。记录
2、患者术中的液体出人量,记录患者人室时(T)、右美托咪定负荷量或生理盐水泵注后(T2)、放置喉罩后()、手术开始后10min(T4)、术毕拔除喉罩后(Ts)、出手术室(T)的HR、SBP、DBP、BIS、Sp02、P盯CO2。观察并记录两组患者术后10min、1h、6h、24h、48h的Ramsay镇静评分和Price-Henry疼痛评分。采用谵妄评定法(CAM)评估术后谵妄发生率。记录术中各种药物的使用情况和术后心动过缓等不良反应的发生情况。结果与C组比较,D组患者舒芬太尼和丙泊酚用量均明显减少(
3、P<0.05),D组T、T5时的SBP、DBP明显下降,T2、T4、Ts时的HR明显减慢(P<0.05)。与C组比较,D组患者在术后10min、1h和6h的Price-henry疼痛评分明显降低(P<0.05)。与术后10min比较,术后6、24和48h的两组Ramsay镇静评分明显降低,D组的Price-hen—ry疼痛评分明显升高(P%0.05)。D组有2例(6.7)患者发生术后谵妄,明显少于C组的8例(26.7)(P4、维持后可以降低老年髋部骨折手术患者术后谵妄的发生率。【关键词】右美托咪定;髋部骨折;麻醉;术后谵妄;老年EffectsofdexmedetomidineonpostoperativedeliriuminelderlypatientsundergoinghipfractureoperationZHENGKe—song,GUEr-wei,LlZha—bing.DepartmentofAnesthesiology,theFtrstAffiliatedHospital,AnhufMedicalUniver5、sity,Hefei230032,ChiraCorrespondingauthor:G(,Er-wei,Email:ay—guew—mz@163.com[Abstract】ObjectiveToexploretheeffectofdexmedetomidineontheincidenceofpostoperativedeliriuminelderlypatientsundergoinghipfractureoperation.MethodsSixtyelderlycasesundergoinghi6、preplacementsurgerywererandomlydividedintodexmedetomidinegroup(groupD)andcontrolgroup(groupC)with30caseseach.IngroupD,dexmedetomidinewasadministeredintravenouslyat0.4肛g·kg一·h一afterabolus(infusionat0.5t~g/kgfor10minwhileanesthesiainduction.GroupCweregi7、ven0.9salinesolutioninsteadofdexmedetomidine.TheindexesofHR,BP,BIS,SpO2,P盯C()2wererecordedatthepatientscameintotheoperatingroom(T1),afterthebolusofdexmedetomidineor0.9salinesolution(T2),afterinsertthelaryngealmask(T3),10minsaftertheoperationbegan(T4),8、afterlaryngealmaskputling(T5),lefttheoperatingroom(T6).ThevalueofRamsayscoresandPrice-Henryscoresaftersurgery10min,1h,6h,24h,48hwererecored,andtherateofpostoperativedeliriumwasevaluatedbyconfusionassessmentmethod.Alsoadverseeffectsandmedicatio
4、维持后可以降低老年髋部骨折手术患者术后谵妄的发生率。【关键词】右美托咪定;髋部骨折;麻醉;术后谵妄;老年EffectsofdexmedetomidineonpostoperativedeliriuminelderlypatientsundergoinghipfractureoperationZHENGKe—song,GUEr-wei,LlZha—bing.DepartmentofAnesthesiology,theFtrstAffiliatedHospital,AnhufMedicalUniver
5、sity,Hefei230032,ChiraCorrespondingauthor:G(,Er-wei,Email:ay—guew—mz@163.com[Abstract】ObjectiveToexploretheeffectofdexmedetomidineontheincidenceofpostoperativedeliriuminelderlypatientsundergoinghipfractureoperation.MethodsSixtyelderlycasesundergoinghi
6、preplacementsurgerywererandomlydividedintodexmedetomidinegroup(groupD)andcontrolgroup(groupC)with30caseseach.IngroupD,dexmedetomidinewasadministeredintravenouslyat0.4肛g·kg一·h一afterabolus(infusionat0.5t~g/kgfor10minwhileanesthesiainduction.GroupCweregi
7、ven0.9salinesolutioninsteadofdexmedetomidine.TheindexesofHR,BP,BIS,SpO2,P盯C()2wererecordedatthepatientscameintotheoperatingroom(T1),afterthebolusofdexmedetomidineor0.9salinesolution(T2),afterinsertthelaryngealmask(T3),10minsaftertheoperationbegan(T4),
8、afterlaryngealmaskputling(T5),lefttheoperatingroom(T6).ThevalueofRamsayscoresandPrice-Henryscoresaftersurgery10min,1h,6h,24h,48hwererecored,andtherateofpostoperativedeliriumwasevaluatedbyconfusionassessmentmethod.Alsoadverseeffectsandmedicatio
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