右美托咪定对妇科腹腔镜手术患者全麻苏醒期的影响.pdf

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1、临床麻醉学杂志2014年1月第3O卷第1期JainAnesthesiol，January2014，vo1．30，No．1·49·．临床研究．右美托咪定对妇科腹腔镜手术患者全麻苏醒期的影响邵娴张瑾邢玉英安丽崔富春吴君娜【摘要】目的评价右美托咪定用于妇科腹腔镜手术患者全麻苏醒期的有效性和安全性。方法择期行妇科腹腔镜手术患者6O例，ASAI或Ⅱ级，采用随机数字表法，随机均分为：右美托咪定组(D组)和对照组(C组)。两组均采用全凭静脉麻醉，手术结束前30minD组患者单次静脉泵注右美托咪定0．5fg／kg，10min内注药完毕。C组以同样方式输注

2、生理盐水。手术结束缝皮前停用静脉麻醉药，手控诱导呼吸。记录患者自主呼吸恢复时间、苏醒时间、拔管时间、Ramsay镇静评分及拔管时患者出现呛咳、躁动等全麻苏醒期不良反应的情况。结果两组呼吸恢复时间、苏醒时间、拔管时间差异均无统计学意义；D组Ramsay镇静评分明显高于C组(P<0．05)。D组呛咳、躁动发生率明显低于C组(P<0．05)。两组在拔管后均未发生呼吸抑制。结论妇科腹腔镜手术患者手术结束前30min单次静脉泵注右美托咪定未发生呼吸抑制及气道不良反应，未延长拔管时间，提高了全麻苏醒期的质量。【关键词】右美托咪定；妇科；全麻；全麻苏醒

3、期Efectsofdexmedetomidineonqualityofemergencefromgeneralanesthesiainpatientsundergoinggynecologicvideolaparoscopicoperation0Xian，ZHANGJin，XINGYu-ying，ANLi，CUIFu．chun，WUJun-na．DepartmentofAnesthesiology，NO．4HospitalD，ShijiazhuangHebeiProvince，ShUiazhuang050000，ChinaCorrespo

4、ndingauthor：ZItANGJin，Emaif：morningzhan&f@163．com[Abstract]ObjectiveToevaluatetheefficacyandsafetyofdexmedetomidineonthequalityofemergencefromgeneralanesthesiainpatientsundergoinggynecologicvideolaparoscopicoperation．MethodsSixtyASAIorIIpatientsundergoinggynecologicvideol

5、aparoscopicoperationwereequallyrandomizedintotWOgroups(=30each)：thedexmedetomidinegroup(groupD)andthecontrolgroup(groupC)．Totalintravenousanesthesia(TIVA)wasusedinthetWOgroups．Dexrnedetomidineat0．5~g／kgwereinfusedover10mininthegroupD30minbeforetheendofsurgery，whilesalinew

6、asusedinthegroupC．Intravenousanestheticswerestopped．Thetimeforrecoveryofspontaneousbreathing，emergencetime，extubationtime，Ramsayscore，andadversereactionswererecorded．ResultsTherewasnosignificantdifferenceinspontaneousbreathingtime．emergencetimeandextubationtimebetweenthet

7、wogroups．ComparedwiththegroupC，theratesofagitation，buckingdecreasedandRamsayscoreincreasedinthegroupD(P<0．O5)．Therewasnorespiratorydepressionafterextubationinthetwogroups．C~tmionTherewasnorespiratorydepressionandairwayincidenceofadverseeventsafterasingledoseinfusionofdexm

8、edetomidine0。5ta／beforetheendofsurgery，andtheextubationtimedidnotincrease．Thequalityofemergencef