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时间:2020-05-02
《七氟醚静-吸复合麻醉对原位肝移植手术患者围术期细胞因子的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·346·临床麻醉学杂志2014年4月第30卷第4期JClinAnesthesiol,April2014,Vol_30,No.4.临床研究.七氟醚静一吸复合麻醉对原位肝移植手术患者围术期细胞因子的影响董兰宇鹏李占军韩曙君【摘要】目的观察七氟醚静一吸复合麻醉对原位肝移植手术患者围术期核因子一B(NF-~B)及肿瘤坏死因子(TNF-~)和白细胞介素一8(IL广8)的影响。方法9o例行经典非转流式原位肝移植手术的终末期肝病患者,随机均分为异氟醚组(I组)和七氟醚组(S组),两组均采用静一吸复合麻醉,静脉麻醉药为丙泊酚。分别于术前(T)、无肝期前(Tz)
2、、无肝期35min(T。)、新肝期30rain(T4)、新肝期2h(T5)及术后12h(T6),静脉采血检测TNF_d及IL-8。新肝再灌注后2h取部分移植肝组织,用于测定肝组织中NF.出蛋白表达量及其入核后与靶基因的结合活性。结果与T时比较,T3~T5时两组患者TNF_a、IL-8水平明显升高(P3、低NF_B、TNF-a和IL-8的表达,减轻肝缺血一再灌注损伤,对保护肝组织有利。【关键词】七氟醚;肝缺血一再灌注损伤;核因子一B;肿瘤坏死因子;白细胞介素一8Perioperativeeffectsofsevoflurane-propofolanesthesiaoneytokinesinpatientsundergoingorthotopicliv—ertransplantationDONGLan,yU,L,Zhan-jun,HANShu-jun.DepartmentofAnesthesiol-ogy,GeneralHospitalofChin4、esePeople'sArmedPoliceForces,Beijing100039,ChinaCorrespondingauthor:Shu—jun,Emaif.dlchina2000@126.com[Abstract]ObjectiveToinvestigatetheperioperativeeffectsofsevoflurane-propofolanesthesiaoncytokinesinpatientsundergoingorthotopic1ivertransplantation.MethodsNinetypatientswithe5、nd-stageliverdiseasewererandomlydividedintothetwogroups:sevofluranegroup(groupS)andisofluranegroup(groupI).Intravenous—inspirationalgeneralanesthesiawasappliedinallpatientswithsevofluraneorisofluranemaintainedrespectively.Serumconcentrati0nsofTNF-aandIL-8weremeasuredbeforeind6、uction(T1),beforeanhepaticstage(T2),35minafteranhepaticstage(T3),30min(T4),2h(T5)and12h(T6)afterneohepaticstage.Hepaticissuewascollectedat2hafterreperfusionstage.ResultsComparedtoT1,TNF_aandI8significantlyincreasedatT3一T5inthetwogroups(P7、wereobviously1oweratT3一T5comparedwithgroupI(P<0.05orP8、iclivertransplantation.Sevofluraneanesthesiamaybeabetterchoiceforliv
3、低NF_B、TNF-a和IL-8的表达,减轻肝缺血一再灌注损伤,对保护肝组织有利。【关键词】七氟醚;肝缺血一再灌注损伤;核因子一B;肿瘤坏死因子;白细胞介素一8Perioperativeeffectsofsevoflurane-propofolanesthesiaoneytokinesinpatientsundergoingorthotopicliv—ertransplantationDONGLan,yU,L,Zhan-jun,HANShu-jun.DepartmentofAnesthesiol-ogy,GeneralHospitalofChin
4、esePeople'sArmedPoliceForces,Beijing100039,ChinaCorrespondingauthor:Shu—jun,Emaif.dlchina2000@126.com[Abstract]ObjectiveToinvestigatetheperioperativeeffectsofsevoflurane-propofolanesthesiaoncytokinesinpatientsundergoingorthotopic1ivertransplantation.MethodsNinetypatientswithe
5、nd-stageliverdiseasewererandomlydividedintothetwogroups:sevofluranegroup(groupS)andisofluranegroup(groupI).Intravenous—inspirationalgeneralanesthesiawasappliedinallpatientswithsevofluraneorisofluranemaintainedrespectively.Serumconcentrati0nsofTNF-aandIL-8weremeasuredbeforeind
6、uction(T1),beforeanhepaticstage(T2),35minafteranhepaticstage(T3),30min(T4),2h(T5)and12h(T6)afterneohepaticstage.Hepaticissuewascollectedat2hafterreperfusionstage.ResultsComparedtoT1,TNF_aandI8significantlyincreasedatT3一T5inthetwogroups(P7、wereobviously1oweratT3一T5comparedwithgroupI(P<0.05orP8、iclivertransplantation.Sevofluraneanesthesiamaybeabetterchoiceforliv
7、wereobviously1oweratT3一T5comparedwithgroupI(P<0.05orP8、iclivertransplantation.Sevofluraneanesthesiamaybeabetterchoiceforliv
8、iclivertransplantation.Sevofluraneanesthesiamaybeabetterchoiceforliv
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