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时间:2020-05-03
《七氟醚丙泊酚静吸复合麻醉对老年患者胃癌根治术术后早期认知功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中国实用医药2014年1月第9卷第3期ChinaPracMed,Jan2014,Vo1.9,No.3·23·七氟醚丙泊酚静吸复合麻醉对老年患者胃癌根治术术后早期认知功能的影响李文英肖琳黄天茎【摘要】目的探讨七氟醚丙泊酚复合麻醉对于老年胃癌患者术后早期认知功能的影响。方法择期食管癌根治术老年患者36例,ASAI-II级,年龄6O一75周岁,随机均分为七氟醚丙泊酚复合麻醉组(S+P组)和丙泊酚全凭静脉组(P组)。分别于手术前1天、术后第3、6、24、72、96h分别测定简易精神状态量表(MMSE)评分。结果与
2、手术前1d比较,两组患者术后3、6hMMSE评分均降低(尸<0.05),但是术后72h仅S+P组评分降低。s组术后出现轻度认知功能障碍的患者为4例(22.2%),P组为2例(11.1%)。结论与丙泊酚全凭静脉麻醉相比,七氟醚丙泊酚复合麻醉并不增加术后早期认知功能障碍的发生率。【关键词】老年患者;术后认知功能障碍;七氟醚;丙泊酚;简易精神状态量表EffectofsevofluraneinhalationcombinedwithintravenouspropofolanesthesiaandpropofolT
3、IVAonpostoperativecognitivefunctioninsenilepatientswithgastriccancerLIWen—ying,XIAOLin,HUANGTian-kun.DepartmentofAnesthesiology,SecondHospitalofLongyan,Longyan364000,China【Abstract】objectiveTocomparetheeffectofsevofluraneinhalationcombinedwithintravenousp
4、ropofolanesthesiaandpropo~ltotalintravenousanesthesia(TIVA)onpostoperativecognitivefunctioninsenilepatientswithgastriccancer.Methods36ASAI~IIpatientsaged60-75yforselectivegastriccancerradicaloperationwererandomlyassignedto2groups.Ingroup(S+P),patientsrece
5、ivedsevofluranecombinedwithintravenouspropofolanesthesiawhereasgroupPpatientsweresubjectedtopropofolTIVAduringtheperiodofgeneralanesthesiamaintenance.Ineithergroup,Mini-mentalstateexamination(MMSE)scoresweremeasuredatday1priortosurgeryaswellas3,6,24,72,96
6、hoursafterpostoperation.ResultsComparedwithpre—anesthesiacondition,MMSEat3and6hoursafterpostoperationfollowingsurgeryattenuatednotablybothin(S+P)groupsandPgroups(P<0.05orP<0.O1)whereas72hourserpostoperationonlystatisticalsignificancewasrecordedin(S+P)grou
7、ps.ConclusionComparedwithTIVA,sevofluraneinhalationcombinedwithintravenousanesthesiamayincreasetherateofpostsurgicalcognitivedysfunctionoccurrence。【Keywords】Elderly;Postoperativecognitivedysfunction;Sevoflurane;Propofol;Mini—mentalstateexamination术后认知功能障碍
8、(postoperativecognitivedysfuction,泊酚全凭静脉麻醉组)。POCD)⋯是指麻醉手术后,患者出现定向力障碍、记忆力和1.2麻醉方法:麻醉维持:S+P组吸入3%的七氟醚复合丙集中力受损和性格精神改变,同时伴认知、人格、社交能力泊酚及瑞芬太尼0.05一O.20kg·min)静脉泵注。P组静脉及技巧的改变,在老年患者中更为常见J。残留的麻醉药物泵注丙泊酚及瑞芬太尼0.05~0.20g/(kg·min)。
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