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《丙泊酚与七氟烷对麻醉术后认知功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2Ol量年10月第39卷第2O期JiangsuMedJ,0ctober2013,V0l39,No.20·论著·丙泊酚与七氟烷对麻醉术后认知功能的影响赵伟新王其敏【摘要】目的比较丙泊酚与七氟烷麻醉对患者术后认知功能的影响。方法择期手术患者6O例,按不同麻醉方法均分为丙泊酚组和七氟烷组两组。比较两组麻醉恢复期相关指标和术后简易精神状态量表(MMSE)认知功能评分。结果丙泊酚组患者术后睁眼时间为(13.2+5.8)min,拔管时间为(15.3土4.5)min,拔管后语言应答时间为(16.8±4.8)min,均短于七氟烷组
2、的(18.9±7.5)min、(24.7±5.9)min、(26.4±5.3)rain(P<0.05)。两组术后认知功能MMSE评分均较术前有所减少,但丙泊酚组术后认知功能MMSE评分高于七氟烷组(P3、ivecognitivefunctionZADWeixin,ⅣGQimin.DepartmentofAnesthesiology,AffiliatedZhengzhouCentralHospital,ZhengzhouUniversity,Zhengzhou450000,CHINA[Abstract10bjectiveTocomparetheinfluenceofpropofolandsevofluraneonthepostoperativecognitivefunctioninpatientsunderwents4、urgery.MethodsAtotalof60casesofsurgicalpatientswasequallyrandomizedintotwogroupsofA(anesthetizedwithpropofolinfusion)andB(anesthetizedwithsevofluraneinhalation).Therecovery-relatedindicatorswererecordedandthepostoperativecognitivefunctionwasevaluatedwithMini—M5、entalStateExamination(MMSE)scoresonthe1st,3rd,7thand10thdayafteroperation.ResultsDuringrecoveryfromanesthesia,thetimesforeye-opening,extubationandlanguageresponsewereshorteringroupAthanthoseingroupBr(13.2±5.8)minvs.(18.9±7.5)min,(15.3±4.5)minvs.(24.7士5.9)minan6、d(16.8±4.8)minvs.(26.4±5.3)mini(P<0.05).Comparedtobefore,MMsEscoresafteroperationwerereduced,whichweregreateringroupBthanthoseingroupA(P<0.05).ConclusionAnesthesiawithpropofolandsevofluranecanreducepostoperativecognitivefunction,whichismorewithsevofluranethant7、hatwithpropofo1.[Keywords]Postoperativecognitivefunction;Propofol;Sevoflurane[JiangsuiviedJ,October2013,39(2O):2443-2444.]术后认知功能障碍是麻醉手术后最常见的中枢(ASA)分级I一Ⅱ级;术前生命体征平稳;无合并心经系统并发症,多见于老年患者,表现为精神错乱、脑血管等重要脏器功能障碍者;既往无中枢神经系焦虑、人格的改变及记忆受损[1]。发生原因尚未明统疾病史者或精神病史者。两组患者性别构成比、确,8、有文献报道,可能与手术、麻醉方式、麻醉药品、年龄、体重、受教育程度、手术时间和手术部位等基患者年龄等因素有关[2]。本文观察了丙泊酚与七氟本资料相仿(P>O.05)。烷麻醉对患者术后认知功能的影响。二、方法资料与方法1.麻醉方法不用术前药,采用全身麻醉。麻一一醉诱导采用依托咪酯、芬太尼、顺苯磺酸阿曲库铵静、般资料择期手术患者60例,男37例,女23例。手术脉
3、ivecognitivefunctionZADWeixin,ⅣGQimin.DepartmentofAnesthesiology,AffiliatedZhengzhouCentralHospital,ZhengzhouUniversity,Zhengzhou450000,CHINA[Abstract10bjectiveTocomparetheinfluenceofpropofolandsevofluraneonthepostoperativecognitivefunctioninpatientsunderwents
4、urgery.MethodsAtotalof60casesofsurgicalpatientswasequallyrandomizedintotwogroupsofA(anesthetizedwithpropofolinfusion)andB(anesthetizedwithsevofluraneinhalation).Therecovery-relatedindicatorswererecordedandthepostoperativecognitivefunctionwasevaluatedwithMini—M
5、entalStateExamination(MMSE)scoresonthe1st,3rd,7thand10thdayafteroperation.ResultsDuringrecoveryfromanesthesia,thetimesforeye-opening,extubationandlanguageresponsewereshorteringroupAthanthoseingroupBr(13.2±5.8)minvs.(18.9±7.5)min,(15.3±4.5)minvs.(24.7士5.9)minan
6、d(16.8±4.8)minvs.(26.4±5.3)mini(P<0.05).Comparedtobefore,MMsEscoresafteroperationwerereduced,whichweregreateringroupBthanthoseingroupA(P<0.05).ConclusionAnesthesiawithpropofolandsevofluranecanreducepostoperativecognitivefunction,whichismorewithsevofluranethant
7、hatwithpropofo1.[Keywords]Postoperativecognitivefunction;Propofol;Sevoflurane[JiangsuiviedJ,October2013,39(2O):2443-2444.]术后认知功能障碍是麻醉手术后最常见的中枢(ASA)分级I一Ⅱ级;术前生命体征平稳;无合并心经系统并发症,多见于老年患者,表现为精神错乱、脑血管等重要脏器功能障碍者;既往无中枢神经系焦虑、人格的改变及记忆受损[1]。发生原因尚未明统疾病史者或精神病史者。两组患者性别构成比、确,
8、有文献报道,可能与手术、麻醉方式、麻醉药品、年龄、体重、受教育程度、手术时间和手术部位等基患者年龄等因素有关[2]。本文观察了丙泊酚与七氟本资料相仿(P>O.05)。烷麻醉对患者术后认知功能的影响。二、方法资料与方法1.麻醉方法不用术前药,采用全身麻醉。麻一一醉诱导采用依托咪酯、芬太尼、顺苯磺酸阿曲库铵静、般资料择期手术患者60例,男37例,女23例。手术脉
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