资源描述：
《老年脓毒症血浆氨基末端脑钠肽前体和肌钙蛋白i 的临床价值.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、老年脓毒症血浆氨基末端脑钠肽前体和肌钙蛋白I的临床价值【摘耍】目的通过联合检测老年脓毒症患者血浆氨基末端脑钠肽前体(NT-proBNP)和肌钙蛋白I(cTnl)质量浓度，评价其对老年脓毒症患者的病情评估及预后判断的临床意义。方法用前瞻性研究方法，以2011年1月至2013年1月在解放军总医院第一附属医院急诊留观及急诊病房住院的老年脓毒症患者145例为研究对象，其屮一般脓毒症组84例、严重脓毒症组45例、脓毒性休克组16例。来院后立即检测血浆NT-proBNP和cTnl质量浓度，行超声心动图检查测定LVEF值，进行A
2、PACHEII评分。随访严重脓毒症及脓毒性休克组患者28d生存情况，对存活组(49例)及死亡组(12例)患者检测的各项指标进行比较；并比较NT-proBNP和cTnl与APACHEII评分的相关性。结果血浆NT-proBNP和cTnl在严重脓毒症组［(1375.48±537.15)pg/mL,(0.53±0.45)ug/L］和脓毒性休克组［(2735.73±907.17)pg/mL,(1.94±1.14)ug/L］的质量浓度明显高于一般脓毒症组［(554.12±107.48)pg/mL,(0.08±0.07)ug/
3、L］,三组间比较差异均具有统计学意义(卩〈0.01)；死亡组血浆NT-proBNP.cTnT质量浓度及APACHEII评分均明显高于存活组，LVEF值明显低于存活组，差异具有统计学意义；血浆NT-proBNP和cTnT质量浓度与APACHEII评分呈正相关。结论血浆NT-proBNP和cTnl质量浓度可用于脓毒症患者的病情评估及预后判断。【关键词】老年人；脓毒症；严重脓毒症；脓毒性休克；氨基末端脑钠肽前体；肌钙蛋白I;射血分数；预后ClinicalvalueofN-terminalpro-brainnatriure
4、ticpeptideandtroponinTplasma1eveIsinelderlypatientswithsepsisSUQin,ZHANGXian,YaoYa-bin,CHENLi-ping,GAOShi-bo,LIUDong-sheng,LIUYang,YAOYong-ming,ZHAOXiao-dong.DepartmentofEmergency,FirstAffiliatedHospital,GeneralHospitalofPLA,Beijing100048,China[Abstract】Object
5、iveToevaluatetheclinicalsignificaneeforassessmentandprognosisofdetectingplasmaNT~proBNPprospectivetrialconducted.sepsiswereadmittedtotheemergencywardfromJanuaryelderpatientswithsepsisbywayofandcTnllevels.MethodsitwasaAtotalof145elderlypatientswithemergencyobse
6、rvationcenterandthe2011throughJanuary2013.Ofthem,therewere84patientswithmildsepsis,45patientswithseveresepsis,and16patientswithsepticshock.PlasmalevelsofNT-proBNPandcTnlwereassayediminediatelyafteradmission.TheLVEFvaluewasdeterminedbyechocardiography.TheAPACHE
7、IIscorewasalsodetermined.Tnthefollowing28daysthesurvivalofpatientswithseveresepsisandsepticshockwereinvestigated・Dataoflaboratoryfindingswereanalyzedforcomparisonbetweenthesurvivalgroup(n二49)anddeathgroup(n=12)•ResuItsTheplasmalevelsofNT-proBNPandcTnlintheseve
8、resepsisgroup[(1375.48±537.15)pg/mL,(0.53±0.45)ug/L]andinthesepticshockgroup[(2735.73土907.17)pg/mL,(1.94±1.14)ug/L]weresignificantlyhigherthanthoseinthemildsepsisgroup[(554.12±107.
