危重儿血清胆碱酯酶与病危程度及预后的相关性分析-论文.pdf

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1、临历研究Linchuangyanjiu《中国医学创新》第11卷第12期(总第294~J)2o14年4月危重儿血清胆碱酯酶与病危程度及预后的相关性分析术樊省廉①何勤①王鹰①【摘要】目的：探讨血清胆碱酯酶对危重儿病危程度及预后的判断价值。方法：按dxJL危重病例评分法(PCIS)进行评分，选取2011年3月一2013年l1月收人本院儿科病房的225例患儿，将其分为非危重组(评分>81分)80例、危重组(评分7l～81分)80例、极危重组(评分<71分)65例，分别于入院后24h内检测血清胆碱酯酶活性，并用多系统器官功能衰竭(MSOF)诊断标准评价系统器官功能，分析血

2、清胆碱酯酶、PCIS评分、MSOF之间的相关性。结果：极危重组血清胆碱酯酶活性明显低于危重组，危重组明显低于非危重组，不同PCIS评分组间的血清胆碱酯酶、MSOF发生率与死亡率比较，PCIS评分越低，血清胆碱酯酶活性越低，多器官功能衰竭发生率越高，死亡率越高，差异均有统计学意义(P

3、inesteraseandDiseaseSevedtyandPrognosisinCriticalIllChildren／FANSheng—lian。HEQin，WANGYingd／MediealInnovationofChina。2014，11(12)：044-046【Abstract】Objective：Toexplorethevalueofserllmcholinesteraseindeterminingthediseaseseverityandprognosisincriticalillchildren．Method：225pediatricpatien

4、tswereadmittedinourpediatricwardsfromMarch2011toNovember2013．AccordingtoPediatricCriticalIllnessScore(PCIS)，theyweredividedintothenon-criticalillgroupfor80CaSes(>81points)，thecriticalillgroupfor80cases(71—81points)andtheextremelycriticalillgroupfor65cases(<71points)．These／umcholinest

5、eraseactivitywasdetectedwithin24hoursafteradmission．ThesystemandorgansfunctionswereevaluatedaccordingtothediagnosticcriteriaofMulti-OrganSystemFailure(MSOF)．ThecorrelationofserumcholinesteraseandPCISscoreandMSOFwasanalyzed．Result：Serumcholinesteraseactivityintheextremelycriticalillgr

6、oupwassignificantlylowerthanthecriticalillgroup，andthatinthecriticalillgroupwassignificantlylowerthanthenon—criticalillgroup．Theserumcholinesterase，MSOFincidenceandmortalitywerecomparedamongdifferentgroupswithdifferentPCISscores．ItwasfoundthatthelowerthePCISscore，thelowertheserumchol

7、inesteraseactivity，thehighertheMSOFincidence，thehigherthemortality，thediferenceswerestatisticallysignificant(P<0．O1)．Conclusion：Accordingtoourresults，thelowerthePCISscore，thelowertheserumcholinesteraseactivity，thehighertheMSOFincidenceandthemortality．Therefore，determiningserumcholine

8、steraseactiv