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时间:2020-03-16
《血清胆碱酯酶与脑梗死的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、血清胆碱酯酶与脑梗死的相关性研究摘要目的探讨急性脑梗死患者血清胆碱酯酶活性与脑梗死的相关性。方法选取在我院住院的201例急性脑梗死患者,将脑梗死组分为非大面积脑梗死组、大面积脑梗死组两组,其中非大面积脑梗死组190例,大面积脑梗死组11例。选取体检中心健康人37例为正常对照组。对脑梗死组与正常对照组的血清胆碱酯酶及血脂、血糖进行检测。并采用统计学软件对实验结果进行统计学意义的分析。结果非大面积脑梗死组胆碱酯酶活性为(11083.33±1968.28)U/L,大面积脑梗死组胆碱酯酶活性为(6844.16
2、±2270.41)U/L,对照组胆碱酯酶活性为(9570.59±1641.25)U/L,非大面积脑梗死组胆碱酯酶较对照组升高(尸二以000),大面积梗死组胆碱酯酶较对照组降低(P=0.003)。根据多元线性回归分析,血清胆碱酯酶与血糖,总胆固醇,甘油三酯呈显著正相关(P<0.05)。LogistiC回归分析提示,血清CHE活性与脑梗死发病密切相关(95%可信区间,P=0.000)。结论血清CHE活性是血糖,甘油三酯,总胆固醇的影响因素,呈正相关。血清胆碱酯酶活性升高与脑梗死的发生相关,大面积脑梗死患者
3、血清胆碱酯酶活性降低,与病情严重程度相关。硕士研究生:刘馨(神经内科)指导老师:潘旭东教授关键词:胆碱酯酶;脑梗死;血脂;血糖TostudytherelationshipbetweenserumcholinesteraseandcerebralinfarctionAbstractObjective:Toinvestigatetherelationshipbetweenserumcholinesteraseactivityinpatientswithacutecerebralinfarctionandc
4、erebralinfarction.Methods:201casesofacutecerebralinfarction,cerebralinfarctionweredividedintononlargesizecerebralinfarctiongroup,largeareacerebralinfarctiongrouptwogroups,nonlargeareacerebralinfarctiongroup190cases,11casesoflargeareacerebralinfarctiongr
5、oup.Thephysicalexaminationcenterand37healthypersonswereselectedasnormalcontrolgroup.Inpatientswithacutecerebralinfarctionandthenormalcontrolgroup,bloodlipid,bloodglucoseweremeasured,serumcholinesteraseactivity.Tosignificanceoftheexperimentalresultsbased
6、ontheanalysisofstatisticalsoftwarestatistical.Results:NonlargeareacerebralinfarctionserumCHEactivity(11083.33-4-1968.28)U/L,thelargesizecerebralinfarctiongroup.TheactivityofserumCHEwas(6844.16-4-2270.41)U/L,serumCHEactivity(9570.594-1641.25)U/L,Highseru
7、mcholinesteraseactivitywassignificantlyhigherthanthecontrolgroupwithoutcerebralinfarctiongroup(P。O),serumcholinesteraseinpatientswithlargeareainfarctiongroupwaslowerthanthecontrolgroup(P=0.003).MultiplelinearregressionanalysisshowedthatserumCHE,glucose,
8、triglyceride,totalcholesterol,influencefactors,significantlypositivecorrelation(P
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