丙泊酚靶控输注麻醉诱导时复合芬太尼对患者效应室丙泊酚浓度和血流动力学的影响-论文.pdf

《丙泊酚靶控输注麻醉诱导时复合芬太尼对患者效应室丙泊酚浓度和血流动力学的影响-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、昆明医科大学学报2014，35(9)：134—137CN53—1221／RJournalofKunmingMedicalUniversity丙泊酚靶控输注麻醉诱导时复合芬太尼对患者效应室丙泊酚浓度和血流动力学的影响方育，黄洁，袁源(昆明医科大学第一附属医院麻醉科，云南昆明650032)[摘要]目的研究丙泊酚靶控输注麻醉诱导时复合芬太尼对患者效应室浓度及血流动力学的影响．方法70例患者分为丙泊酚组(P组，n=35)和芬太尼组(F组，n=35)．2组患者均用丙泊酚靶控诱导；F组在输注丙泊酚前3min

2、静脉注射芬太尼2~g／kg，P组不使用芬太尼．分别记录麻醉诱导开始前(T1)、意识消失时即睫毛反射消失时(T2)、气管插管完成时(T3)患者的平均动脉压及心率．记录开始TCI输注丙泊酚至患者意识消失的时间、意识消失时的效应室丙泊酚浓度以及开始TCI输注丙泊酚至插管完成时两组患者的丙泊酚用量．结果P组，I’2时间点平均动脉压及心率较T1显著降低，T3较T1明显升高；F组T2时间点平均动脉压及心率较T1显著降低．F组从TCI输注丙泊酚开始至患者意识消失所需的时间、丙泊酚的效应室浓度和丙泊酚剂量均较P

3、组明显降低．结论2p~g／kg的芬太尼可以降低患者意识消失的丙泊酚效应室浓度，缩短诱导时间，减少丙泊酚的使用量，有效的抑制插管引起的心血管反应，使诱导过程中患者的血流动力学更加稳定．[关键词]芬太尼；丙泊酚；靶控输注；效应室浓度；血流动力学[中图分类号]R614[文献标识码]A[文章编号]2095-610X(2014)09—0134—04InfluenceofTarget-controlledInfusionofPropofolCombinedwithFentanylontheEfect-sit

4、eConcentrationofPropofolandHemodynamicsduringInductionofAnesthesiaFANGYu，HUANGJie，YUANYuan(Dept．ofAnesthesiology，The5AffiliatedHospitalofKunmingMedicalUniversity，KunmingYunnan650032，China)[Abstract]ObjectiveTostudytheinfluenceoftarget-controlledinfus

5、ionofpropofolcombinedwithfentanylontheeffect—siteconcentrationofpropofolandhemodynamicsduringinductionofanesthesia．MethodsSeventypatientswererandomlydividedintotwogroups(groupPandgroupF)，35patientseach．GroupFreceivedfentanyl2~g／kg3minintravenouslybef

6、oretheinfusionofpropofol，whilegroupPdidnotreceivefentany1．Be~reinductionofanesthesia(T1)，atthetimeofthelossofconsciousness(T2)andthetimeoftrachealintubation(T3)ineachgroup，themeanarterialpressure(MAP)andheartrate(HR)wererecorded．Thetimefromtheinfusio

7、nofpropofoltothelossofconsciousness，theeffect-siteconcentrationofpropofolatthetimeofthelossofconsciousnessandthedosageofpropofolwhenintubationfinishedwererecorded，respectively．ResultsMAPandHRwerelowersignificantlyatT2andmuchhigheratT3comparedwithT1in

8、groupP，andMAPandHRwerelowersignificantlyatT2comparedwithT1ingroupF．Thetimefromtheinfusionofpropofoltothelossofconsciousness，theeffect——siteconcentrationofpropofolatthetimeofthelossofconsciousnessandthedoseofpropofolwhenintubationfinishedwerelowersign