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《顺铂和香菇多糖胸腔内注射治疗老年肺癌伴胸腔积液.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、2012年8月第38卷第15期JiangsuMedJ,August2012,Vo138,No.15论著顺铂和香菇多糖胸腔内注射治疗老年肺癌伴胸腔积液夏春伟陈文萍徐玲徐小峰【摘要】目的观察胸腔内置管注入顺铂和香菇多糖治疗老年肺癌伴胸腔积液的疗效。方法肺癌性胸腔积液老年(70—87岁)患者120例,随机均分为顺铂组(A组)、香菇多糖组(B组)和顺铂+香菇多糖组(C组)。经皮胸腔内置管引流尽胸液后,向胸腔内注药,观察治疗效果。结果总有效率:A组55.0%,B组52.5,C组77.5;C组总有效率高于A组和B组(P2、老年肺癌性胸腔积液疗效好,不良反应少。【关键词】肺癌;胸腔积液;顺铂;香菇多糖【中图分类号】R734【文献标识码】A【文章编号10253—3685(2012)15—1805—03Treatingsenilepatientswithlungcancer-inducedpleuraleffusionwithintrathoracicinjectionofcisplatinandlentinanXIAChunwei,CHENWengping,XULing,eta1.NanjingChestHospiptal,Naing210029。CHINA[Abstract3、]ObjectiveToobservetheclinicalefficacyoftreatingsenilepatientswithlungcancer—inducedpleuraleffusionusingintrathoracicinjectionofcisplatinandlentinan.MethodsAtotalof120senilepatientswithmalignantpleuraleffusioncausedbylungcancerwasequallyrandomizedintothreegroupsofA(treatedwithcis4、platin),B(treatedwithlentinan)andC(treatedwithbothcisplatinandlentinan).Intrathoracicadministrationwasperformedsoonafterdrainageofpleuraleffusion.Thecurativeeffecwasevaluated.ResultsThetotaleffectivenessrateingroupCwas77.5,whichwassignificantlyhigherthan55.0ingroupAand52.5ingroup5、B(P<0.05).ConclusionComparedtocisplatinorlentinanalone。combinedintrathoracicadministrationofcisplatinandlentinanhasbetterefficacyinthetreatmentofsenilepatientswithlungcancer-inducedpleuraleffusionwithlittleadversereactions.[Keywords]Lungcancer;Pleuraleffusion;Cisplatine;Lentinan[6、JiangsuMedJ,August2012,38(15):1805—1807.]作者单位:210029江苏省,南京市胸科医院呼吸病科通讯作者:陈文萍其引发的持续性、系统性炎症状态可能是导致[5]CatalanV,Gomez-AmbrosJJ,RodriguezA,eta1.Increasedcirculatingandvisceraladiposetissueexpression1evelsofYKL,40升高的原因之一。血清YKL-40可能参与YKL一40inobesity-associatedtype2diabetesarerelatedto了胰岛7、素抵抗及T2DM的发生发展。inflammation:impactofconventionalweightlossandgastric参考文献bypass[J].JClinEndocrinolMeta,2011,96(1):200—209.L1]宁光.脂肪炎症因子在2型糖尿病发病中的重要性[J].中华内[6]HempenM,KoppHP,ElhenickyM,eta1.YKL-40iselevated分泌代谢杂志,2006,22(2):221—223.inmorbidlyobesepatientsanddeclinesafterweightlossEJ]8、.[2]RathekeCN,JohansenJS,Vestergaard}LYK
2、老年肺癌性胸腔积液疗效好,不良反应少。【关键词】肺癌;胸腔积液;顺铂;香菇多糖【中图分类号】R734【文献标识码】A【文章编号10253—3685(2012)15—1805—03Treatingsenilepatientswithlungcancer-inducedpleuraleffusionwithintrathoracicinjectionofcisplatinandlentinanXIAChunwei,CHENWengping,XULing,eta1.NanjingChestHospiptal,Naing210029。CHINA[Abstract
3、]ObjectiveToobservetheclinicalefficacyoftreatingsenilepatientswithlungcancer—inducedpleuraleffusionusingintrathoracicinjectionofcisplatinandlentinan.MethodsAtotalof120senilepatientswithmalignantpleuraleffusioncausedbylungcancerwasequallyrandomizedintothreegroupsofA(treatedwithcis
4、platin),B(treatedwithlentinan)andC(treatedwithbothcisplatinandlentinan).Intrathoracicadministrationwasperformedsoonafterdrainageofpleuraleffusion.Thecurativeeffecwasevaluated.ResultsThetotaleffectivenessrateingroupCwas77.5,whichwassignificantlyhigherthan55.0ingroupAand52.5ingroup
5、B(P<0.05).ConclusionComparedtocisplatinorlentinanalone。combinedintrathoracicadministrationofcisplatinandlentinanhasbetterefficacyinthetreatmentofsenilepatientswithlungcancer-inducedpleuraleffusionwithlittleadversereactions.[Keywords]Lungcancer;Pleuraleffusion;Cisplatine;Lentinan[
6、JiangsuMedJ,August2012,38(15):1805—1807.]作者单位:210029江苏省,南京市胸科医院呼吸病科通讯作者:陈文萍其引发的持续性、系统性炎症状态可能是导致[5]CatalanV,Gomez-AmbrosJJ,RodriguezA,eta1.Increasedcirculatingandvisceraladiposetissueexpression1evelsofYKL,40升高的原因之一。血清YKL-40可能参与YKL一40inobesity-associatedtype2diabetesarerelatedto了胰岛
7、素抵抗及T2DM的发生发展。inflammation:impactofconventionalweightlossandgastric参考文献bypass[J].JClinEndocrinolMeta,2011,96(1):200—209.L1]宁光.脂肪炎症因子在2型糖尿病发病中的重要性[J].中华内[6]HempenM,KoppHP,ElhenickyM,eta1.YKL-40iselevated分泌代谢杂志,2006,22(2):221—223.inmorbidlyobesepatientsanddeclinesafterweightlossEJ]
8、.[2]RathekeCN,JohansenJS,Vestergaard}LYK
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