肝豆状核变性患者的记忆监测研究-论文.pdf

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1、·420·中华行为医学与脑科学杂志2014年5月第23卷第5期ChinJBehavMed＆BrainSci．May2014．Vo1．23N0．5．·临床研究·肝豆状核变性患者的记忆监测研究任婧陈新贵韩永升马慧娟汪凯【摘要】目的研究肝豆状核变性病(HLD)患者记忆监测的情况，同时探讨HLD患者记忆障碍的可能机制。方法建立情景记忆(EM)及语义记忆(SM)的知道感(FOK)实验范式，对3O例HLD患者及3O例年龄及教育程度相匹配的健康对照者(HC)进行研究。结果与HC组的FOK—EM的线索回忆率[(64．17+29．21

2、)％]以及FOK—SM的线索回忆率[(84．72+11．44)％]比较，HLD患者组FOK—EM的线索回忆率[(26．55±20．92)％]、FOK—SM的线索回忆率[(53．93±28．42)％]显著降低，差异有统计学意义(t=一5．140，19<0．01；f=一5．123，P<0．01)；FOK—EM的肯定判断／正确再认成绩[(50．64+29．43)％]、否定判断／正确再认成绩[(12．80~18．32)％]与HC组的肯定判断／正确再认成绩[(75．15+31．73)％]、否定判断／正确再认成绩[(1．81±5

3、．41)％]之间差异有统计学意义(=-2．693，P

4、hWilson’sflseaseRenJing，ChenXing~i，HanYongsheng，MaHui一n，WangKai．DepartmentofNeurology，theFirstHospitalofAnhuiMedicalUniversity，Hefei230922，China【Abstract】0bjectiveToinvestigatethememorymonitoringabilityinpatientswithhepatolenticularde—generation(HLD)andexploret

5、hemechanismoftheirmemoryimpairment．MethodsThefeeling—of-knowing(FOK)paradigmofepisodicmemory(EM)andsemanticmemory(SM)wereestablishedandsubsequentlyappliedto30HLDpatientsand30healthycontrol(HC)participantswhowerematchedinageandeducationalleve1．Re-suitsComparedwi

6、thhealthycontrolgroup(FOK—EMrecall(64．17±29．21)％；FOK—SMrecall(84．72±11．44)％)，theFOK—EMrecall((26．55±20．92)％)andFOK—SMrecall((53．93±28．42)％)inHLDpatientsweresignificantlylower(一5．140，P<0．01；一5．123，P<0．01)．ThepositivejudgmentandcorrectrecognitionofFOK—EM((50．64~2

7、9．43)％)andthenegativejudgmentandcorrectrecognitionofFOK—EM((12．80~18．32)％)intheHLDgroupweresignificantlydifferentfromtheHCgroup(thepositivejudgmentandcorrectrecognitionofFOK—EM：(75．15±31．73)％andthefalsejudgmentandcorrectrecognitionofFOK—EM：(1．81-4-5．41)％；t=一2．6

8、93，P<0．05；f=3．026，P<0．01)．Mostimportantly，thestroopeffectwaspositivelycorrelatedwiththenegativejudgmentandcorrectrecognitionofFOK—EMinHLDgroup(r=0．601，P<0．01)．ConclusionTher