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1、[经典]缺血性脑血管病介入治疗对炎性细胞因子影响的研究缺血性脑血管病介入治疗对炎性细胞因子影响的研究【摘耍】目的观察缺血性脑血管病患者相关血管开通前后致炎细胞因子肿瘤坏死因子-a(TNF-CI)、白细胞介>-6(IL-6)和抗炎细胞因子白细胞介素-10仃1厂10)的动态变化。方法采用酶联免疫吸附法测定30例健康人(健康对照组)和30例缺血性脑血管病患者急诊介入治疗术前即刻、术后12、24h,血浆TNF-ci、IL-6、IL-10的变化,比较致炎细胞因子TNF-a、TL-6和抗炎细胞因子TL-10的动态变化。结果再灌注前急诊介入组患者TNF-ci、T
2、I厂6显著高于健康对照组(卩〈0・05),血浆IL-10略高于健康对照组,但差异无统计学意义(P>0.05);再灌注后12、24h急诊介入组患者血浆TNF-a、TI厂6、TI厂10均较术前显著增高(P〈0・01,P〈0・05)。急诊介入组患者再灌注治疗后12h抗炎细胞因子TL-10的升高幅度显著低于致炎细胞因子TNF-a、儿-6的升幅(P〈0・01)。结论缺血性脑血管病再灌注后致炎细胞因子较抗炎细胞因子增高更显著。❷【关键词】缺血性脑血管病;再灌注损伤;肿瘤坏死因子-a;白细胞介素-6;白细胞介素T0Theinflueneeofemergencyp
3、ercutaneousinterventiononplasmacytokinesinpatientswithischemiccerebrovasculardiseaseYTNDong-1iang,DTNGYan-ping・DepartmentofNeurology,TheThirdMunicipalHospitaiofJinanCity,Shandong250031,China[Abstract】ObjectiveToobservethedynamicchangesoftumornecrosisfactor-alphainterleukin~6an
4、dinterleukin一10inpatientswithischemiccerebrovasculardisease(ICVD)beforeandafterrecanalizationofinfarct-relatedartery.MethodsIn30IVCDpatientsand30normalpeopleasacontrolgroup,plasmaTNF-a,IL-6andIL-10weremeasuredbyELISAbeforeemergencypercutaneousintervention,12hand24hpost-interve
5、ntion.AmplitudesofchangesinplasmaTNF-a,IL~6andIL~10werecompared・ResultsPlasmaIL-10inICVDwasnotsignificantlyhigherthanthatincontrolgroup(P>0・05)beforeemergencypercutaneousintervention,butTNF-aandIL~6significantlyhigher(P〈0・05)・PlasmaTNF一a,IL~6andIL-10at12hand24hpost-interventio
6、nweresignificantlyhigherthanthosebeforepercutaneousintervention(P<0.01,P〈0・01,P〈0・05),buttheamplitudeofIL-10increasewassignificantlylessthanthatofTNF-a,IL-6(P<0・01)・ConclusionTNF-a,IL-6andIL-10maybeinvolvedinischemia-reperfusioninjury.Theimbalancebetweeninflammation-promotinga
7、ndanti-inflammatorycytokinesmaybeoneofthemechanismsresultinginischemia-reperfusioninjury.❷[Keywords】Ischemiccerebrovasculardisease;Ischemia-reperfusioninjury;Tumornecrosisfactor-alpha;Interleukin-6;Intedeukin-10目前,随着介入材料的不断完善及神经介入技术的成熟,经皮腔内血管成形和支架植入术(PTAS)介入治疗是当前治疗缺血性脑血管病(ICVD
8、)最有效的方法之一,它显著改善ICVD患者的近期和远期预后,但缺血再灌注损伤的存在部分限制其有益作用。既往的研究已表明,缺