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《不同剂量舒芬太尼复合曲马多用于烧伤患儿术后镇痛的比较.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、临床麻醉学杂志2014年8月第3O卷第8期JClinAnesthesiol,August2014,Vo1.30,No.8.临床研究.不同剂量舒芬太尼复合曲马多用于烧伤患儿术后镇痛的比较罗国占陈明湖曾伟莫优炼【摘要】目的比较不同剂量舒芬太尼复合曲马多用于烧伤患儿术后静脉镇痛(PCIA)的效果,并探讨舒芬太尼适宜剂量。方法拟于全身麻醉下择期行躯干或四肢烧伤瘢痕整形术患儿6o例,年龄3~10岁,ASAI或Ⅱ级,随机均分为A、B、C组。术毕前3Omin给予负荷量舒芬太尼0.15tag/kg,术后接镇痛泵,其中A组舒芬太尼0.03tag·kg·h一
2、,B组舒芬太尼0.04tag·kg·h一,C组舒芬太尼0.05tag·kg·h一;三组均复合曲马多0.3mg·kg·h一。分别在术后即刻(T)、6h()、12h(Ts)、24h(T4)和48h()采用改良面部表情评分法观察镇痛效果,记录FLACC评分和Ramsay镇静评分。观察并记录PCA按压次数及呼吸抑制、恶心、呕吐、头晕等不良反应。结果与A组比较,~时B组和C组面部表情评分、FLACC评分明显降低、Ramsay镇静评分明显升高(P3、,B组和C组tK;A有效按压次数明显减少,C组恶心呕吐、头晕发生率明显升高(P<0.05)。与B组比较,C组PCA有效按压次数明显减少、恶心呕吐、头晕发生率明显升高('P4、patientsL∞Guo-zhan,CHENMing-hu,z啪We,MOYou.1ian.DepartmentofAn—esthesiology,BOAIHospitalofZhongshan,Zhongshan528400,ChinaCorrespondingauthor:L∞Guo-zhan,Emaif_luoguozhan1978@126.corn[Abstract]ObjectiveTocomparethepostoperativeanalgesiceffectofdifferentdosesofsufen—tamlcombi5、nedwithtramadolinpediatricburnpatients。andfindoutthepropersufentanildosage.MethodsSixtypediatricburnpatients,ASAIorII,3-10yearsold,wererandomlydividedintothreegroups(groupA,groupB,groupC).Allchildrenweregivengenera1anesthesia,andgivensul—fentanil0.15tag/kg30minbeforetheen6、dofoperation.ThechildreningroupAweregivensullen~tanil0.03g·kg一·h一withtramadol0.3mg·kg~·h,ingroupBsulfentanil0.04g·kg一·h一withtramadol0.3mg·kg一·h一,andingroupCsulfentanil0.05g·kg一·h~withtramadol0.3mg·kg~·h~.Recordtheheartrate,meanarteria1pressure,respiratoryrate,Sp02,improve7、facespainratingscale.FLACCanalgesiascale.Ramsaysedationscaleandadversereactionat0h,6h,12h,24h,48hafteroperation(Tl—T5).ResultsTherewerenosignificantdifferencesinanalgesiaeffectsforeachgroupattheendofoperation.ButthereweresignificantdifferencesinanalgesiaeffectsingroupsBan8、dCcomparedwithgroupA(P<0.05).Thehigherthesulfentanildose,thelowervalidpressnumberwasobserved.The
3、,B组和C组tK;A有效按压次数明显减少,C组恶心呕吐、头晕发生率明显升高(P<0.05)。与B组比较,C组PCA有效按压次数明显减少、恶心呕吐、头晕发生率明显升高('P4、patientsL∞Guo-zhan,CHENMing-hu,z啪We,MOYou.1ian.DepartmentofAn—esthesiology,BOAIHospitalofZhongshan,Zhongshan528400,ChinaCorrespondingauthor:L∞Guo-zhan,Emaif_luoguozhan1978@126.corn[Abstract]ObjectiveTocomparethepostoperativeanalgesiceffectofdifferentdosesofsufen—tamlcombi5、nedwithtramadolinpediatricburnpatients。andfindoutthepropersufentanildosage.MethodsSixtypediatricburnpatients,ASAIorII,3-10yearsold,wererandomlydividedintothreegroups(groupA,groupB,groupC).Allchildrenweregivengenera1anesthesia,andgivensul—fentanil0.15tag/kg30minbeforetheen6、dofoperation.ThechildreningroupAweregivensullen~tanil0.03g·kg一·h一withtramadol0.3mg·kg~·h,ingroupBsulfentanil0.04g·kg一·h一withtramadol0.3mg·kg一·h一,andingroupCsulfentanil0.05g·kg一·h~withtramadol0.3mg·kg~·h~.Recordtheheartrate,meanarteria1pressure,respiratoryrate,Sp02,improve7、facespainratingscale.FLACCanalgesiascale.Ramsaysedationscaleandadversereactionat0h,6h,12h,24h,48hafteroperation(Tl—T5).ResultsTherewerenosignificantdifferencesinanalgesiaeffectsforeachgroupattheendofoperation.ButthereweresignificantdifferencesinanalgesiaeffectsingroupsBan8、dCcomparedwithgroupA(P<0.05).Thehigherthesulfentanildose,thelowervalidpressnumberwasobserved.The
4、patientsL∞Guo-zhan,CHENMing-hu,z啪We,MOYou.1ian.DepartmentofAn—esthesiology,BOAIHospitalofZhongshan,Zhongshan528400,ChinaCorrespondingauthor:L∞Guo-zhan,Emaif_luoguozhan1978@126.corn[Abstract]ObjectiveTocomparethepostoperativeanalgesiceffectofdifferentdosesofsufen—tamlcombi
5、nedwithtramadolinpediatricburnpatients。andfindoutthepropersufentanildosage.MethodsSixtypediatricburnpatients,ASAIorII,3-10yearsold,wererandomlydividedintothreegroups(groupA,groupB,groupC).Allchildrenweregivengenera1anesthesia,andgivensul—fentanil0.15tag/kg30minbeforetheen
6、dofoperation.ThechildreningroupAweregivensullen~tanil0.03g·kg一·h一withtramadol0.3mg·kg~·h,ingroupBsulfentanil0.04g·kg一·h一withtramadol0.3mg·kg一·h一,andingroupCsulfentanil0.05g·kg一·h~withtramadol0.3mg·kg~·h~.Recordtheheartrate,meanarteria1pressure,respiratoryrate,Sp02,improve
7、facespainratingscale.FLACCanalgesiascale.Ramsaysedationscaleandadversereactionat0h,6h,12h,24h,48hafteroperation(Tl—T5).ResultsTherewerenosignificantdifferencesinanalgesiaeffectsforeachgroupattheendofoperation.ButthereweresignificantdifferencesinanalgesiaeffectsingroupsBan
8、dCcomparedwithgroupA(P<0.05).Thehigherthesulfentanildose,thelowervalidpressnumberwasobserved.The
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