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1、Zbl.Vet.Med.B,28,483-493(1981)@1981VerlagPaulParey,BerlinundHamburgISSN0721-1856/Intercode.ZVRBAZDepartmentofVeterinaryPathology,StateUniversityofGhent,BelgiumDirector:Prof.Dr./.HoorensNationalInstituteofVeterinaryResearch,Brussels,BelgiumDirector:Dr.J.LeunenLaboratoryofVirology,
2、StateUniversityofGhent,BelgiumDirector:Prof.Dr.M.PenszertThree-dimensionalSequentialStudyoftheIntestinalSurfaceinExperimentalPorcineCV777CoronavirusEnteritisBYR.DUCATELLE,W.COUSSEMENT,G.CHARLIER,P.DEBOUCKandJ.HOORENSWith9figures(ReceivedforprrblicdonApril13,1980)IntroductionViral
3、enteritisinpigletsisusuallyassociatedwithTransmissibleGastro-enteritisVirusorwithPorcineRotavirus.In1978,anewcoronavirus-likeagentwasdetectedintheintestinalcontentsofpigletswithdiarrhoea(11).TheagentwasshowntodifferantigenicallyfromtheporcinecoronavirusesTrans-missibleGastro-ente
4、ritisVirusandHaemagglutinatingEncephalomyelitisVirus.Theclinicalaspectsofthediseaseandthevirologicalaspectsofthecausativeagenthavebeendescribed(2).Themorphogenesisofthevirusisalsocharacteristicforamemberofthecoronaviridaefamily(15).Histopathological,histochemical(COUSSEMENTetal.,
5、tobepublished),ultrastructural(DUCA-TELLEetal.,tobepublished)andimmunofluorescencestudies(DEBOUCKetal.,tobepublished)oftheintestineincaesarean-derived,colostrum-deprivedpig-letshavebeendone.Thesestudieshaveshownthatthelesionsandthedistri-butionoftheviralantigenaresimilartoTransmi
6、ssibleGastro-enteritisViralinfection,althoughwithsomerestrictions:thelesionsareslightlylesssevere,andthevirusalsoreplicatesinthecolonicepitheliumbutwithoutcausinganyhistologicallesions.Thepurposeofthepresentstudyistodescribethealterationsoftheintestinalsurfaceandtorelatethemtopos
7、siblemechanismsofdiarrhoea,bycomparingwithknownenteriticconditionsinpiglets.U.S.CopyrightClearanceCenterCodeStatement:0721-1856/81/2806-0483$02.50/0484DUCATELLE,COUSSEMENT,CHARLIER,DEBROUCKandHOORENSMaterialandMethodsAthree-dimensionalstudywasdonebystereo-microscopy,histologyoflo
8、ngitudinalandtransversesections,andscann
