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1、ArchivesofVirologyArchivesofVirology79,85--94(1984)©bySpringer-Vertagt984ExperimentalStudiesofaCoronairusandCoronavirus-LikeAgentinaBarrier-MaintainedFelineBreedinflColonyByC.A.STOI)DA~I~T,J.E.BARLOUGtI,andF.W.SCOTTCornellFelineHealthCenterandDepartmentofMicrobiolog
2、y,NewYorkStateCollegeofVeterinaryMedicine,Cornel1University,Ithaca,NewYork,U.S.A.With1FigureAcceptedAugust15,1983SummaryMinimM-disease(MD)catsraisedinabarrier-maintainedfelinebreedingcolonyroutinelybecomecoronavirus(CV)antibody-positiveat5-8weeksofageandremainseropo
3、sitiveindefinitely.Inaddition,theyshedcorona-virus-likeparticles(CVLPs)intheirfeceswhicharemorphologicallydistinctfrom"typical"coronaviruses.0ronasal,intraperitoneal,intraduodenal,andintravenousinoculationsofCVLPswereuniformlyunsuccessfulintheseroconversionofeatstoC
4、V,whereassubsequentprolongedclosecontactwithcolonyeatsdidresultinseroconversion.SuchevidenceindicatesthatMDeatsinthisbarriercolonyareinfectedwithatleasttwonon-cross-reactiveagents:(1)felineentericCVLPs,whichareshedinfecesandaremorphologicallyandantigenicMlydistinctf
5、romestablishedcoronaviruses(CVs),and(2)aviruswhichisantigenicallycross-reactivewithCVs,butwhichisapparentlyshedbysomerouteotherthanthelowergastrointestinaltract.IntroductionFelineinfectiousperitonitisvirus(FIPV)isarecognizedmemberofthefamilyCoronaviridae(2,18)andisa
6、ntigenicallyrelatedtotransmissiblegastroenteritisvirus(TGEV)ofswine,caninecoronavirus(CCV),andhumanrespiratorycoronavirus229E(HCV229E)(8,15,17,20).FIPV-likeparticleshavebeenidentifiedinthegastrointestinaltractsofsomecatswithfelineinfectiousperitonitis(FIP)(6,7)anden
7、teritis(5,14),andinfecesofapparentlyhealthycats(N.C.PED~RS~:~',personalcommunication).AnentericvirusmorphologicallyandantigenicallysimilartoFIPVhasbeenreportedfromcatsrearedinaconventionalfelinebreedingcolonymaintained86C.A.STODDART,J.E.BARI;OUGI-I,andF.W.ScoT~:byAn
8、imalResourcesServices,UniversityofCalifornia,Davis(14),andisreferredtohereasFECV(UCD).Thisviruswasinitiallydetectedinfecesofhealthycatsbut
