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1、SymposiumonAdvancesinFelineMedicineISerodiagnosticAidsandManagementPracticeforFelineRetrovirusandCoronavirusInfectionsJeffreyE.Barlough,D.V.M.,Ph.D.*VirusparticleswerefirstvisualizedbyJarrettetal.33in1964infelinelymphosarcoma(LSA)tissue,andinfelineinfectiousper
2、itonitis(FIP)lesionsbyZooketal.58in1968.Sincetheseearlyreports,muchhasbeenlearnedaboutbothoftheseviralagents.Thefelineleukemiavirus(FeLV)isahorizontallyandverticallytransmittedretrovirusandisthecausativeagentofthemostimportantfatalinfectiousdiseasecomplexoftheA
3、mericandomesticcats.43TheFIPvirus(FIPV)isahorizontallytransmittedcorona•virusthatistheincitingagentofalethal,immunologicallymediateddiseasecharacterizedbyfibrinousserositisanddisseminatedperivasculitis.7Safeandefficaciousvaccinesarestillunavailableforbothofthes
4、evirlsinfections.Thus,untilsuchvaccinesaredeveloped,controloftheseinfectionsmustbebasedonaccurateidentificationandisolationofdiseasedanimalsandasymptomatic,chroniccarriers.FELINERETROVIRUSINFECTIONSReplication-competentretrovirusescarrywiththemauniqueandfascin
5、atingenzymecalledreversetranscriptase.26Thisenzymeiscapableofgeneratingadeoxyribonucleicacid(DNA)copyoftheretroviralgenomethatistheninsertedintothechromosomalDNAoftheinfectedcell.Thisalienintruder,knownasaprovirusorproviralDNA,thenisreplicatedwheneverhost-celld
6、ivisiontakesplaceandcanserveasatemplatefortheintracellularproductionofnewvirusparticles.Thenewvirionsareassem•bledinthecytoplasmofthecellandarereleasedatthecellmembrane,wheretheyacquirealipidenvelopeandglycoproteinsurfacereceptors*PresentlyResearchAssociate,Ore
7、gonStateUniversityCollegeofVeterinaryMedicine,CorvalliS,Oregon;formerlyGraduateResearchAssistant,DepartmentofMicrobiology,NewYorkStateCollegeofVeterinaryMedicine,andStaffMember,CornellFelineHealthCenter,CornellUniversity,Ithaca,NewYorkVeterinaryClinicsofNorthAm
8、erica:SmallAnimalPractice-Vol.14,No.5,September1984955956JEFFREYE.BARLOUGH(peplomers).Acellinfectedwitharetrovirusisinfectedessentiallyforthedurationofitsexistence,asareallo
