英汉对照分子生物学导论 Chapter 0 Introduction

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1、YongWangDepartmentofBiotechnolgySchoolofFoodandBiologicalEngineeringJiangsuUniversityZhenjiang212013P.R.ChinaE-mail:ywang@ujs.edu.cnAbilingualcourseforundergraduatesMolecularBiologySylvainW.LapanDepartmentofBiologyMassachusettsInstituteofTechnologyCambridgeMassa

2、chusetts02139U.S.A.E-mail:slapan@MIT.eduPreparedby&TextbookAnIntroductionofMolecularBiologywithChineseTranslation《英汉对照分子生物学导论》SylvainW.Lapan王勇TeachingActivityTimeTeachingactivityFirstpartUseEnglishtoteach(60minutes)用英语教学SecondpartUseChinesetoexplainthe(30minutes

3、)majorpoints用汉语对主要内容进行讲解JamesD.Watsonetc.MolecularBiologyoftheGeneReferencebooksBenjaminLewinGeneVIIIIntroduction/引言1.Whatismolecularbiology?什么是分子生物学？2.Whatshouldwelearn?我们应该学习什么内容？3.Howtolearn?如何学习？1.Whatismolecularbiology?Molecularbiology:“Howdoesasetofmolecul

4、esmakeadynamiclivingorganism?”Themostfundamentalfeatureofallknownlifeistheabilitytoreproduceandtheabilitytogrow.Iforganismswerenotabletoreproduce,lifewouldbeimpossible.Ifthecelldoesnotgrow,…400kg200kg100kg50kg25kg12.5kgG0G1G2G3G4G5G66.3kg3.1kgG7Atiger?You’rekidd

5、ingme!ThecellgrowsbeforeitdividesDivideGrowDivideProteinsarethekeyplayerReproductionandgrowtharelargelytheworkofproteins.DivideGrowDivideProteinsProteinsProteinsNucleicacids:theinformationcarrierInformationformakingproteinsisstoredinnucleicacids.ProteinsNucleica

6、cids(mainlyDNA)ThecentraldogmaTranscriptionProteinsNucleicacids(mainlyDNA)RNATranslationMolecularbiologystudies…Molecularmechanismsofeverystepinthecentraldogma.中心法则每一步的分子机理2.Whatshouldwelearn?MolecularmechanismsofDNAreplication,transcriptionandtranslation.DNA复制、

7、转录和转译的分子机理。Molecularmechanismsoftranscriptionalandtranslationalregulation.转录与转译调控的分子机理。MolecularmechanismsofDNArecombinationandmutationrepairetc.DNA重组与突变修复等的分子机理。3.Howtolearn?Becausewehavesomanythingstolearn,itisveryeasytogetlostinthesedetails,andsobeforewebegin

8、tostudy,weneedsomeguidingprinciplestogiveasenseofordertomanyofthesedetails.因为我们有这么多内容要学，而一旦深入到细节中又很容易迷失方向，因此在开始学习之前，我们需要一些指导原则来帮助梳理这些细节内容。Theguidingprinciples/指导原则1)E