[经典]阿曲库铵持续推注用于老年患者的临床效果

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1、［经典］阿曲库较持续推注用于老年患者的临床效果阿曲库鞍持续推注用丁老年患者的临床效果【摘要】目的观察阿曲库鞍持续输注用于老年患者维持全麻肌松的临床效果。方法40例拟行气管内全麻下择期手术的老年患者(ASACII),在常规进行快诱导及气管插管后5min内，首次静注阿曲库鞍0.5mg/kg后，随机分为2组皿组，持续输注阿曲库鞍0.3、0.5mg/(kg•h)；B组,根据需要间断推注阿曲库鞍0.2、0・3mg/kgo原则上以维持肌松程度恒定。A组于手术结束前25min停止给药，两组麻醉维持以安氟醸吸入及芬太尼间断静注，均待患者

2、自主呼吸自然恢复(不予肌松药拮抗剂)o观察两组单位时间内阿曲库鞍平均用药量(mg/(kg•min)>停止给药后肌松的恢复率(min)>手术结束至气管导管拔管时间(min).手术结束前15min内因麻醉减浅而体动的例数及需要追加镇静药或镇痛药次数。结果两组患者一般情况、病种及手术时间差异无统计学意义(P>0.05)；阿曲库鞍平均总用量差异无显著性(0.40±0.05mg/(kg•h)vsB组0.40±0.07mg/(kg•h),P>0.05)；肌松恢复率差异显著(A组15.4±5.5minvsB组2

3、8±6・1min,P<0.01)；拔管时间差异显著(A组10.5±2.8minvsB组20.2±3・6min,P<0.01)；手术结束前体动的例数A组少于B组(A组0次vsB组6次，P〈0.05)；需要追加镇静或镇痛次数(A组0次vsB组10次，P<0.05)o结论持续推注阿曲库鞍用于老年患者维持全麻肌松是一种较为方便并易于控制的方法。【关键词】阿曲库鞍；神经肌肉阻滞；老年患者；用药方法Comparisonbetweenthecontinuousinfusionandintermittedadministrationofatracu

4、riumintheagedpatientsZHUANGYa-ying,WANGHong-geng,CHENRu-ping,WANGYan-hui・DepartmentofAnesthesiology,JinjiangHospital,Fujian362200,China.[Abstract]ObjectiveTocomparetheclinicaleffectsofatracuriumbyintervalbolusorcontinuousinfusionduringsurgeryintheaged.MethodsFortyASAIo

5、rIIelderpatientsundergoingelectivesurgerywererandomlyassignedtotwogroups(groupAandgroupB,n二20ineachgroup)・FortypatientsreceivedaninitialbolusofO.5mg/kgatracuriumfollowedbyaninfusionof0.3~0.5mg/(kg•h)(groupA)orbyintervalbolusof0.2、0・3mg/kg(groupB).Thedegreeofneuro

6、nuscularblockadeandrecoverytimeofmusclerelaxantswerestudiedwithmornitingneuronusculartransmissionbytrain-offourstimulation.Thedosesofatracuriumandextubationtimefromtheendofsurgerywereobserved・ResultsThemeandosesofatracuriumingroupAwere0・40±0・05mg/(kg•h)vs0.40±0.0

7、7mg/(kg•h)ingroupB(P>0.05).TherecoverytimeofmusclerelaxantsingroupAwas15.4±5・5minvs28±6・1miningroupB(P<0.05).TheextubationtimefromtheendofsurgeryingroupAwas10.5±2.8minvs20.2±3.6miningroupB(P<0・01).Theleverofneuronuscularblockadewithintervalboluswasunatableandpoor

8、lycontrolled・ConclusionConelusionInfusionofatracuriumcanbemoreeasilycontrolledthanintermittedadministrationduringsurg