资源描述：
《113.Immune development and intestinal microbiota in celiac disease. 》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、HindawiPublishingCorporationClinicalandDevelopmentalImmunologyVolume2012,ArticleID654143,12pagesdoi:10.1155/2012/654143ReviewArticleImmuneDevelopmentandIntestinalMicrobiotainCeliacDiseaseTamaraPozo-Rubio,1MartaOlivares,2EstherNova,1GiadaDePalma,2JorgeR.M
2、ujico,1MariaDesamparadosFerrer,2AscensionMarcos,´1andYolandaSanz21ImmunonutritionResearchGroup,DepartmentofMetabolismandNutrition,InstituteofFoodScience,TechnologyandNutrition,SpanishNationalResearchCouncil(ICTAN-CSIC),CalleJos´eAntonioNovais,10,28040Mad
3、rid,Spain2MicrobialEcologyandNutritionResearchGroup,InstituteofAgrochemistryandFoodTechnology,SpanishNationalResearchCouncil(IATA-CSIC),AvenidaAgust´ınEscardino,7.Paterna,46980Valencia,SpainCorrespondenceshouldbeaddressedtoYolandaSanz,yolsanz@iata.csic.e
4、sReceived6June2012;Revised6August2012;Accepted13August2012AcademicEditor:FranciscoJ.Perez-Cano´Copyright©2012TamaraPozo-Rubioetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andre
5、productioninanymedium,providedtheoriginalworkisproperlycited.Celiacdisease(CD)isanimmune-mediatedenteropathy,triggeredbydietarywheatglutenandsimilarproteinsofbarleyandryeingeneticallysusceptibleindividuals.Theetiologyofthisdisorderiscomplex,involvingboth
6、environmentalandgeneticfactors.ThemajorgeneticriskfactorforCDisrepresentedbyHLA-DQgenes,whichaccountforapproximately40%ofthegeneticrisk;however,onlyasmallpercentageofcarriersdevelopthedisease.Glutenisthemainenvironmentalfactorresponsibleforthesignsandsym
7、ptomsofthedisease,butexposuretoglutendoesnotfullyexplainthemanifestationofCD.Epidemiologicalandclinicaldatasuggestthatenvironmentalfactorsotherthanglutenmightplayaroleindiseasedevelopment,includingearlyfeedingpractices(e.g.,breastmilkversusformulaanddura
8、tionofbreastfeeding),infections,andalterationsintheintestinalmicrobiotacomposition.Herein,wereviewwhatisknownabouttheinfluenceofdietaryfactors,exposuretoinfectiousagents,andintestinalmicrobiotacomposition,particularlyinearl
