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1、InternationalImmunology,Vol.22,No.1,pp.7–12InternationalImmunology,Vol.25,No.4,pp.207–214InternationalImmunology,Vol.22,No.1,pp.7–12©TheJapaneseSocietyforImmunology.2013.Allrightsreserved.PublishedbyOxfordUniversityPressonbehalfofPublishedbyOxfordUniversityPresson
2、behalfofdoi:10.1093/intimm/dxp112doi:10.1093/intimm/dxs116doi:10.1093/intimm/dxp112Forpermissions,pleasee-mail:journals.permissions@oup.comTheJapaneseSocietyforImmunology2009.TheJapaneseSocietyforImmunology2009.AdvanceAccesspublication23November2009AdvanceAccesspu
3、blication15January2013AdvanceAccesspublication23November2009IL-21andTfollicularhelpercellsRegulationofintestinalmicrobiotabytheNLRIL-21andTfollicularhelpercellsRosanneSpolskiprotein familyRosanneSpolskiandandWarrenJ.LeonardWarrenJ.LeonardLaboratoryofMolecularImmun
4、ology,NationalHeart,Lung,andBloodInstitute,Building10,Room7B05,Bethesda,LaboratoryofMolecularImmunology,NationalHeart,Lung,andBloodInstitute,Building10,Room7B05,Bethesda,MD20892-1674,USAAmlan BiswasMD20892-1674,USA1,2,3and KoichiS. Kobayashi1,2,31DepartmentofMicro
5、bialandMolecularPathogenesis,TexasA&MHealthScienceCenter,TX77843,USACorrespondencetoCorrespondenceto:W.J.Leonard;E-mail:wjl@helix.nih.gov:W.J.Leonard;E-mail:wjl@helix.nih.gov2DepartmentofCancerImmunology&AIDS,Dana-FarberCancerInstitute,Boston,MA02215,USAReceived3R
6、eceived25September2009,25September2009,acceptedaccepted30October200930October2009DepartmentofMicrobiologyandImmunobiology,HarvardMedicalSchool,Boston,MA02215,USAAbstractCorrespondencetoAbstract:K. S.Kobayashi.DepartmentofMicrobialandMolecularPathogenesisCollegeofM
7、edicineTexasA&MHealthScienceCenter,415AReynoldsMedicalBuilding,CollegeStation,TX77843,USA;E-mail:kobayashi@medicine.tamhsc.edu11Uponencounterwithantigen,CD4Uponencounterwithantigen,CD4TcellsdifferentiateintoeffectorTTcellsdifferentiateintoeffectorThsubsetswithdist
8、inctivehsubsetswithdistinctivefunctionsthatarerelatedtotheiruniquecytokineprofilesandanatomicallocations.OneofthemostReceivedfunctionsthatarerelatedtothe
