资源描述：
《48.The Gastrointestinal Microbiome Alcohol Effects on the Composition of Intestinal Microbiota》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ALCOHOLRESEARCH:SPECIALSECTIONCurrentReviewsComputer-basedandInternetPrevention,AlcoholScreening,Computer-basedandInternetPrevention,AlcoholScreening,ALCOHOLRESEARCH:CurrentReviewsFOCUSONandBriefInterventionislinkedwithtissueinjuryandorgandysfunction,includ-TheGastrointestinalingalcoholicliv
2、erdisease(ALD)(Purohitetal.2008),increasedriskofdevelopingcancer(SeitzandStickel2007),Microbiomeabnormalfunctionoftheimmunesystemthatincreasestheriskofacuteandchronicinfections(SzaboandMandrekar2009),pancreatitis(ChowdhuryandGupta2006),heartdisease(LiedtkeandDeMuth1975),anddisruptionoftheAlc
3、oholEffectsontheCompositioncircadianclock(Spanageletal.2005).Theobservationthatonlysomealcoholicsdevelopalcohol-inducedpathologyofIntestinalMicrobiotaindicatesthat,althoughalcoholisnecessary,itisnotsufficienttocauseorgandysfunction.Consequently,factorsotherthanthetoxicityofalcoholareinvolved
4、ingeneratinghealthPhillipA.Engen;StefanJ.Green,Ph.D.;RobinM.Voigt,Ph.D.;complications,oneofwhichmaybealcohol-inducedchangesChristopherB.Forsyth,Ph.D.;andAliKeshavarzian,M.D.inintestinalmicrobiotacompositionand/orfunction.Theintestinalmicrobiotaisclassifiedasthetotalcollec-Theexcessiveuseofal
5、coholisaglobalproblemcausingmanytionofmicrobialorganisms(bacteriaandmicrobes)withinadversepathologicalhealtheffectsandasignificantfinancialthegastrointestinaltract(GIT).Itcontainstensoftrillionshealthcareburden.Thisreviewaddressestheeffectofalcoholofmicroorganisms,includingatleast1,000differ
6、entspeciesconsumptiononthemicrobiotainthegastrointestinaltractofknownbacteria,thevastmajorityofwhichbelongtothe(GIT).Althoughdataarelimitedinhumans,studieshighlightphylaFirmicutesandBacteroidetes(Leyetal.2008).Thetheimportanceofchangesintheintestinalmicrobiotainalcohol-metagenomeisthecollect
7、ionofallthedifferentgenesfoundrelateddisorders.Alcohol-inducedchangesintheGITmicrobi-withinthegutmicrobiome;theGITmicrobiomecontainsotacompositionandmetabolicfunctionmaycontributetothemorethan3millionuniquegenes,outnumberingthenumberwell-establishe
