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1、TheJournalofNutritionCriticalReviewCanNutritionalModulationofMaternalIntestinalMicrobiotaInfluencetheDevelopmentoftheInfant1,2GastrointestinalTract?3,44,534,67CarolineThum,AdrianL.Cookson,DonE.Otter,WarrenC.McNabb,AlisonJ.Hodgkinson,4,83,4JolonDyer,andNicoleC.Roy*3FoodNutritionandHealthTeam,
2、FoodandBio-basedProductsGroup,AgResearchGrasslands,PalmerstonNorth,NewZealand;45RiddetInstitute,MasseyUniversity,PalmerstonNorth,NewZealand;RumenMicrobiologyTeam,AnimalNutritionandHealth67Group,AgResearchGrasslands,PalmerstonNorth,NewZealand;AgResearchGrasslands,PalmerstonNorth,NewZealand;D
3、airy8FoodsTeam,FoodandBio-basedProductsGroup,AgResearchRuakura,Hamilton,NewZealand;andFoodandBio-basedProductsGroup,AgResearchLincoln,Christchurch,NewZealandDownloadedfromAbstractThegastrointestinalmicrobiotaplaysanimportantroleinmaintaininghosthealthbypreventingthecolonizationofpathogens,f
4、ermentingdietarycompounds,andmaintainingnormalmucosalimmunity.Particularlyinearlylife,thecompositionofthemicrobiotaprofoundlyinfluencesthedevelopmentandmaturationofthegastrointestinaltract(GIT)mucosa,whichmayaffecthealthinlaterlife.Therefore,strategiestomanipulatethemicrobiotaduringinfancyma
5、yjn.nutrition.orgpreventthedevelopmentofsomediseaseslaterinadultlife.EarlierresearchsuggestedthattermfetusesaresterileandthattheinitialbacterialcolonizationofthenewbornGIToccursonlyafterthebabytransitsthroughthebirthcanal.However,recentstudieshavedemonstratedthatthecolonizationand/orcontact
6、ofthefetuswiththematernalGITmicrobiotamaystartinutero.Aftervaginalbirth,thecolonizationoftheneonateGITcontinuesthroughcontactwithbyguestonApril1,2014maternalfecesandvaginalbacteria,leadingtoarelativelysimplemicrobialcommunitythatisinfluencedbyfeedingtype(breastvs.formulafeeding).MaternalGITm
7、icrobiota,vaginalmicrobiota,andbreastmilkcompositionareinfluencedbymaternaldiet.AlterationsofthematernalGITmicrobiotacompositionviasupplementationwithprobioticsandprebioticshavebeenshown;however,transferofthesebenefitstotheoffspringremainstobedemonstrated.
